Evidence map›Paper›PMID 41546750›Full record

ArticleHeart failure reviews2026

Rationale and design of MUSIC-HFpEF: a phase 1b, pilot trial evaluating the safety and pharmacodynamic effects of AAV1.SERCA2A in heart failure with preserved ejection fraction.

Marat Fudim, Satyam Sarma, James P MacNamara, Deborah D Ascheim, Veraprapas Kittipibul, Katheryn Doukellis, Andy Dhimitri, Robert Fitzhugh, Niharika Kamat, Kevin D Costa and 9 more

Abstract readClinical Trial, Phase IMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart failure reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Marat FudimDuke University Medical Center, Durham, NC, USA. marat.fudim@duke.edu.
Satyam SarmaInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian, Dallas, TX, USA.
James P MacNamaraInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian, Dallas, TX, USA.
Deborah D AscheimD2A, Ltd, Los Angeles, CA, USA.
Veraprapas KittipibulDuke University Medical Center, Durham, NC, USA.
Katheryn DoukellisDuke University Medical Center, Durham, NC, USA.
Andy DhimitriDuke University Medical Center, Durham, NC, USA.
Robert FitzhughDuke University Medical Center, Durham, NC, USA.
Niharika KamatMedera Biopharma, Boston, MA, USA.
Kevin D CostaMedera Biopharma, Boston, MA, USA.
Jeffrey RudyMedera Biopharma, Boston, MA, USA.
Janet GuerreroMedera Biopharma, Boston, MA, USA.
Camie ChanMedera Biopharma, Boston, MA, USA.
Ronald A LiMedera Biopharma, Boston, MA, USA.
Anthony A BavryUT Southwestern Medical Center, Dallas, TX, USA.
Manesh R PatelDuke University Medical Center, Durham, NC, USA.
Justin L GrodinUT Southwestern Medical Center, Dallas, TX, USA.
Benjamin D LevineInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian, Dallas, TX, USA.
Roger J HajjarGene & Cell Therapy Institute, Mass General Brigham, Boston, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure with preserved ejection fraction (HFpEF) has limited therapeutic options. Abnormal calcium handling through impaired sarcoplasmic/endoplasmic reticulum Ca

Indexed as

DependovirusGenetic TherapyHeart FailureSarcoplasmic Reticulum Calcium-Transporting ATPasesStroke VolumeAgedEchocardiographyFemaleGenetic VectorsHumansMaleMiddle AgedPilot ProjectsSarcoplasmic Reticulum Calcium-Transporting ATPasesCalcium handlingClinical trialGene therapyHeart failure with preserved ejection fractionSERCA2a

Identifiers

PMID41546750
PMCPMC12812093

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.