Evidence map›Paper›PMID 41546785›Full record

ReviewJournal of molecular histology2026

Structural and functional comparative analysis of porcine and human salivary glands: a narrative review for translational research.

Lara Vanelli, Giovanna P Florezi, Cristina Massoco, Silvia Vanessa Lourenço

Abstract readReviewComparative Study
In one paragraph

Review in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lara VanelliStomatology Department, Faculdade de Odontologia da Universidade de São Paulo, São Paulo, São Paulo, Brasil.ORCID http://orcid.org/0009-0005-4713-5193
Giovanna P FloreziStomatology Department, Faculdade de Odontologia da Universidade de São Paulo, São Paulo, São Paulo, Brasil. giovanna.florezi@usp.br.ORCID http://orcid.org/0000-0002-5328-0937
Cristina MassocoLaboratory of Comparative Imuno-Oncology, Department of Pathology, Faculdade de Medicina Veterinária da Universidade de São Paulo, São Paulo, São Paulo, Brasil.ORCID http://orcid.org/0000-0001-8030-0609
Silvia Vanessa LourençoStomatology Department, Faculdade de Odontologia da Universidade de São Paulo, São Paulo, São Paulo, Brasil.ORCID http://orcid.org/0000-0002-6704-8549

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of animal models plays a crucial role in advancing our understanding of human diseases, providing valuable insights into pathophysiological mechanisms and supporting the development of innovative therapeutic strategies. Among the available models, porcine models have been recognized as particularly relevant due to their anatomical, genetic, and physiological similarities to humans. Notably, this review provides the first comprehensive comparative analysis of porcine and human salivary glands, integrating anatomical, functional, and translational perspectives. Porcine salivary glands offer a promising platform for comparative studies, as they share both structural and functional characteristics with human salivary tissue. This review highlights the anatomical and functional parallels between porcine and human salivary glands, emphasizing their significance in biomedical research. In recent years, porcine models have been increasingly employed in studies investigating disease mechanisms, drug efficacy and toxicity, as well as regenerative medicine. The integration of these models into translational research is expected to facilitate the development of novel therapeutic approaches and improve clinical outcomes in human patients. Ongoing research on the application of porcine models remains essential for refining current methodologies and expanding the scope of salivary gland studies related to human health and disease.

Indexed as

Salivary GlandsTranslational Research, BiomedicalAnimalsDisease Models, AnimalHumansSwineAnimal modelsComparative anatomyPigsSalivaSalivary glandsXerostomia

Identifiers

PMID41546785
PMCPMC12812082

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.