ArticleBMC psychiatry2026
Association of depressive symptoms with systemic immune-inflammation index and platelet parameters among survivors of myocardial infarction: a cross-sectional NHANES study enhanced by machine learning and SHAP analysis.
Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Explainable prediction of MDR/RR-TB in tuberculosis-diabetes mellitus multimorbidity: a machine learning model developed and validated in a dual-center study.BMC infectious diseases · 2026Article
- Sex-related molecular phenotypes in anxiety-depressive disorders: a machine learning analysis of routine blood biomarkers.Frontiers in psychiatry · 2026Article
- Systemic immune-inflammation index combined with blood urea nitrogen to albumin ratio predicts 28-day mortality in sepsis: a retrospective cohort study.Frontiers in physiology · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundInflammation is implicated in the elevated risk of depressive disorder following myocardial infarction (MI), with platelets serving as a key link between thrombosis, inflammation, and depression. Although the systemic immune-inflammation index (SII), platelet count (PLT), and mean platelet volume (MPV) are readily accessible hematological parameters, their associations with post-MI depressive symptoms remain underexplored. This study investigates these relationships in MI survivors, augmented by machine learning (ML) and SHapley Additive exPlanations (SHAP) analysis for enhanced predictive insights.
methodsThis cross-sectional study utilized data from 1,352 adults with self-reported MI history in the National Health and Nutrition Examination Survey (NHANES) 2009-2020. Multivariable logistic regression, subgroup analyses, dose-response curves, and sensitivity analyses were conducted to assess independent associations between depressive symptoms (Patient Health Questionnaire-9 score ≥ 5) and log
resultsIn multivariable regression, log
conclusionsIn a nationally representative U.S. sample, elevated log CLINICAL TRIAL NUMBER: Not applicable.
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