Evidence map›Paper›PMID 41547730›Full record

ArticleBMC medical imaging2026

Feasibility of neurite oriented diffusion and density imaging in thigh skeletal muscle of volunteers with knee pain: relationship with proton density fat fraction: a cross-sectional study.

Yiou Wang, Ziru Qiu, Juan Liu, Yanjun Chen, Xinru Zhang, Ruoxing Liao, Dong Han, Xinyuan Zhang, Xiaodong Zhang

Abstract read
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In one paragraph

Article in BMC medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yiou Wang *Department of Medical Imaging, The Third Affiliated Hospital Southern Medical University, 183 Zhongshan Ave. W, Guangzhou, 510630, China.
Ziru QiuDepartment of Radiology, Zengcheng Branch of Nanfang Hospital, Guangzhou, China.
Juan LiuStatistics Office, The Third Affiliated Hospital Southern Medical University, Guangzhou, 510630, China.
Yanjun ChenDepartment of Medical Imaging, The Third Affiliated Hospital Southern Medical University, 183 Zhongshan Ave. W, Guangzhou, 510630, China.
Xinru ZhangDepartment of Medical Imaging, The Third Affiliated Hospital Southern Medical University, 183 Zhongshan Ave. W, Guangzhou, 510630, China.
Ruoxing LiaoSouthern Medical University, Guangzhou, 510515, China.
Dong HanStatistics Office, The Third Affiliated Hospital Southern Medical University, Guangzhou, 510630, China.
Xinyuan ZhangSchool of Biomedical Engineering, Southern Medical University, Guangzhou, China. zhangxyn@smu.edu.cn.
Xiaodong ZhangDepartment of Medical Imaging, The Third Affiliated Hospital Southern Medical University, 183 Zhongshan Ave. W, Guangzhou, 510630, China. ddautumn@126.com.

Funding

the Guang Dong Basic and Applied Basic Research Foundation 2023A1515012093the Guang Dong Basic and Applied Basic Research Foundation 2024A1515010352the National Natural Science Foundation of Chin 82471928
6 · The paper itself

Abstract

objectivesTo evaluate the microstructure changes in thigh skeletal muscles of volunteers with knee pain and to explore their relationship with the proton density fat fraction (PDFF), utilizing neurite oriented diffusion and density imaging (NODDI). MATERIALS AND

methodsIn this prospective study, we collected NODDI and mDIXON-quant images from the bilateral thigh skeletal muscles of 66 asymptomatic and 24 knee pain volunteers. To optimally match the raw data based on these variables and create asymptomatic group (HC, n = 24) and knee pain group (KP, n = 24), the MatchIt package was utilized. STATISTICAL TESTS: For the comparison of normally distributed data between the HC and KP groups, t-tests were utilized, while the Wilcoxon rank-sum test was applied for non-normally distributed data. Pearson coefficient was used to analyze the correlation between microstructure parameters of thigh skeletal muscle and PDFF.

resultsStatistically significant differences were observed in MD value of the left hamstrings between the HC and KP groups (p = 0.030), as well as in the FA value of the right quadriceps femoris (p = 0.026). Among volunteers experiencing knee pain, the V-intra value of the right hamstrings and the FA value of the right quadriceps femoris demonstrated a moderate positive correlation with PDFF (r = 0.661, p < 0.001; r = 0.724, p < 0.001).

conclusionMicrostructure differences in thigh skeletal myofibrils were detected in volunteers with knee pain compared to asymptomatic volunteers, and were more closely related to intramuscular fat infiltration.

Indexed as

ArthralgiaDiffusion Magnetic Resonance ImagingKnee JointMuscle, SkeletalNeuritesAdipose TissueAdultCross-Sectional StudiesFeasibility StudiesFemaleHumansMaleMiddle AgedProspective StudiesProtonsThighProtonsKnee painMicrostructureNeurite oriented diffusion and density imagingProton density fat fractionSkeletal myofibrils

Identifiers

PMID41547730
PMCPMC12896115

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.