Evidence map›Paper›PMID 41548155›Full record

ArticleBiogerontology2026

Shaker potassium channel mediates an age-sensitive neurocardiac axis regulating sleep and cardiac function in Drosophila.

Kishore Madamanchi, Dalton Bannister, Ariel Docuyanan, Shruti Bhide, Girish C Melkani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biogerontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Kishore Madamanchi *Department of Pathology, Division of Molecular and Cellular Pathology, Heersink School of Medicine, The University of Alabama, Birmingham, AL, 35294, USA.
Dalton Bannister *Department of Biology, Molecular Biology Institute, San Diego State University, San Diego, CA, 92182, USA.
Ariel DocuyananDepartment of Biology, Molecular Biology Institute, San Diego State University, San Diego, CA, 92182, USA.
Shruti BhideDepartment of Biology, Molecular Biology Institute, San Diego State University, San Diego, CA, 92182, USA.
Girish C MelkaniDepartment of Pathology, Division of Molecular and Cellular Pathology, Heersink School of Medicine, The University of Alabama, Birmingham, AL, 35294, USA. girishmelkani@uabmc.edu.

Funding

Research Development CoreP30AG050886 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$1.2M
NIA NIH HHS P30 AG050886NIA NIH HHS R01 AG065992NIH HHS AG065992
6 · The paper itself

Abstract

The Shaker (Sh) gene in Drosophila melanogaster encodes a voltage-gated potassium channel that regulates neuronal excitability and is well known for its role in sleep regulation; however, its contribution to cardiac physiology and neurocardiac communication remains insufficiently explored. In this study, we investigated how two Sh-mutations (Sh

Indexed as

AgingDrosophila ProteinsHeartShaker Superfamily of Potassium ChannelsSleepAnimalsCircadian RhythmDrosophila melanogasterMutationNeuronsDrosophila ProteinsShaker Superfamily of Potassium ChannelsSh protein, DrosophilaAge-linked cardiac dysrhythmiaDrosophila Shaker mutationNeurocardiac axisSleep-cardiac linkageSleep-circadian cycleTime-restricted feedingVoltage-gated potassium channels

Identifiers

PMID41548155
PMCPMC12812776

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.