Evidence map›Paper›PMID 41549070›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Sulfate-Directed Silver Dendrites with Enhanced Stability for Ultrasensitive SERS-Based Therapeutic Drug Monitoring.

Aradhana Dwivedi, Jan Dellith, Anna Makarova, Samir F El-Mashtoly, Juergen Popp, Vladimir Sivakov, Dana Cialla-May

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aradhana DwivediLeibniz Institute of Photonic Technology, Member of Leibniz Health Technologies, Member of the Leibniz Centre For Photonics in Infection Research (LPI), Jena, Germany.
Jan DellithLeibniz Institute of Photonic Technology, Member of Leibniz Health Technologies, Member of the Leibniz Centre For Photonics in Infection Research (LPI), Jena, Germany.
Anna MakarovaHelmholtz-Zentrum Berlin für Materialien Und Energie, Berlin, Germany.
Samir F El-MashtolyLeibniz Institute of Photonic Technology, Member of Leibniz Health Technologies, Member of the Leibniz Centre For Photonics in Infection Research (LPI), Jena, Germany.
Juergen PoppLeibniz Institute of Photonic Technology, Member of Leibniz Health Technologies, Member of the Leibniz Centre For Photonics in Infection Research (LPI), Jena, Germany.
Vladimir SivakovLeibniz Institute of Photonic Technology, Member of Leibniz Health Technologies, Member of the Leibniz Centre For Photonics in Infection Research (LPI), Jena, Germany.
Dana Cialla-MayLeibniz Institute of Photonic Technology, Member of Leibniz Health Technologies, Member of the Leibniz Centre For Photonics in Infection Research (LPI), Jena, Germany.ORCID https://orcid.org/0000-0002-8577-1490

Funding

Bundesministerium für Forschung, Technologie und Raumfahrt 01DN23003Deutsche Forschungsgemeinschaft 465289819Helmholtz-Zentrum-Berlin HZB 231-11802-ST
6 · The paper itself

Abstract

Silver-based surface-enhanced Raman spectroscopy (SERS) substrates offer exceptional signal enhancement but suffer from poor long-term stability due to oxidative degradation, limiting their utility for real-world applications. Here, we introduce sulfate-directed silver dendrites (s-AgDs) as oxidation-resistant SERS substrates with extended shelf life, reproducible signal performance, and sub-picomolar sensitivity. Sulfate ions promote anisotropic growth and form a surface-associated sulfate layer, resulting in dendritic morphologies with high hot-spot density and suppressed surface oxidation. The AgDs demonstrate robust SERS performance over seven months under ambient conditions. We demonstrate translational utility by detecting five clinically relevant drugs in aqueous and blood plasma matrices with minimal pretreatment and excellent reproducibility. These results establish s-AgDs as a stable, reproducible, and application-ready SERS platform for point-of-care therapeutic drug monitoring.

Indexed as

Drug MonitoringSilverSpectrum Analysis, RamanSulfatesHumansMetal NanoparticlesReproducibility of ResultsSilverSulfatespoint‐of‐care platformsensitivitySilver Dendrites (AgDs)silver sulfatestabilitySurface‐Enhanced Raman Spectroscopy (SERS)therapeutic drug monitoring

Identifiers

PMID41549070
PMCPMC13042930

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.