Evidence map›Paper›PMID 41549103›Full record

ArticleAnnals of hematology2026

Neuro-related gene signatures predict prognosis in diffuse large B-Cell lymphoma and uncover TRPV2-mediated tumor microenvironment regulation.

Boyuan Su, Siyu Qian, Yukai Duan, Feiyang Zong, Wanyue Zhao, Yue Zhang, Mingzhi Zhang, Yunfei Song, Xudong Zhang, Qingjiang Chen

Abstract read
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In one paragraph

Article in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Boyuan Su *Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Siyu Qian *Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yukai DuanDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Feiyang ZongDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Wanyue ZhaoDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yue ZhangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Mingzhi ZhangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yunfei SongDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Xudong ZhangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. fcczhangxd@zzu.edu.cn.
Qingjiang ChenDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. qingjiang_c@zzu.edu.cn.

Funding

Fundamental Research Funds of Henan Academy of Innovations in Medical Science JBKY250321Henan Provincial Natural Science Foundation General Project 252300421358Henan Provincial Science and Technology Research Project SBGJ202001008
6 · The paper itself

Abstract

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous malignancy. Although the R-CHOP regimen has significantly improved the prognosis for most patients, a subset continues to experience poor therapeutic outcomes. Recent studies have highlighted the role of the nervous system in cancer, yet its impact on DLBCL remains unclear. In this study, 21 neuro-related (NR) genes were identified from the Gene Ontology database, and a prognostic risk scoring model for DLBCL was developed and validated across multiple cohorts. The NR-based score effectively stratified patients according to survival outcomes. The high NR score group was characterized by an immunosuppressive microenvironment, activation of pro-proliferative pathways, and increased mutation frequencies of oncogenes such as TP53 and MYC. In contrast, the low NR score group exhibited enriched inflammatory responses and immune activation signals. The key gene TRPV2, associated with favorable prognosis, was found to promote M1-like polarization in monocytes/macrophages and enhance antigen presentation in B cells. This study establishes the NR risk score as a novel prognostic tool for DLBCL and underscores neuro-immune interactions as potential therapeutic targets.

Indexed as

Calcium ChannelsLymphoma, Large B-Cell, DiffuseTranscriptomeTRPV Cation ChannelsTumor MicroenvironmentCyclophosphamideFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMalePrognosisVincristineCalcium ChannelsCyclophosphamideTRPV2 protein, humanTRPV Cation ChannelsVincristineDiffuse large B-cell lymphomaNeurobiologyPrognostic modelTumor microenvironment

Identifiers

PMID41549103
PMCPMC12812782

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.