Evidence map›Paper›PMID 41549135›Full record

ArticleInflammation2026

miR-221 Exerts Antiviral and Anti-Inflammatory Effects against HSV-1 Through Direct Repression of CAMK2A and Immune Pathway Activation.

Jiahao Xu, Lianhong Xu, Die Hu, Ying Zhang, Yongfang Wang, Zhihua Yun

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jiahao XuDepartment of Laboratory Medicine, Wujin Hospital Affiliated with Jiangsu University, Jiangsu University, Changzhou, 213000, China. wjyyxujiahaoand@163.com.
Lianhong XuDepartment of Laboratory Medicine, Wujin Hospital Affiliated with Jiangsu University, Jiangsu University, Changzhou, 213000, China.
Die HuDepartment of Laboratory Medicine, Wujin Hospital Affiliated with Jiangsu University, Jiangsu University, Changzhou, 213000, China.
Ying ZhangDepartment of Laboratory Medicine, Wujin Hospital Affiliated with Jiangsu University, Jiangsu University, Changzhou, 213000, China.
Yongfang WangDepartment of Laboratory Medicine, Wujin Hospital Affiliated with Jiangsu University, Jiangsu University, Changzhou, 213000, China.
Zhihua YunDepartment of Laboratory Medicine, Wujin Hospital Affiliated with Jiangsu University, Jiangsu University, Changzhou, 213000, China.

Funding

Clinical Technology Development Foundation of Jiangsu University No. JLY20180097the Science and Technology Project (Social Development) of Wujin District No. WS201941
6 · The paper itself

Abstract

Herpes simplex virus type 1 (HSV-1) triggers significant inflammation and immune dysregulation, particularly in immunocompromised hosts. MicroRNA-221 (miR-221) is implicated in viral pathogenesis and inflammatory responses, yet its role in HSV-1 infection remains undefined. This study demonstrates that miR-221 suppresses HSV-1 replication, with 100 nM miR-221 reducing plaque formation by approximately 70% and markedly decreasing infectious viral titers (TCID

Indexed as

Anti-Inflammatory AgentsAntiviral AgentsCalcium-Calmodulin-Dependent Protein Kinase Type 2Herpes SimplexHerpesvirus 1, HumanMicroRNAsAnimalsMiceMice, Inbred C57BLVirus ReplicationAnti-Inflammatory AgentsAntiviral AgentsCalcium-Calmodulin-Dependent Protein Kinase Type 2Camk2a protein, mouseMicroRNAsMIRN221 microRNA, mouseAntiviral immunityCalcium signaling​CAMK2AHSV-1MiR-221

Identifiers

PMID41549135
PMCPMC12882962

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.