Evidence map›Paper›PMID 41549277›Full record

ArticleMolecular cancer2026

METTL3-mediated m

Chaotao Chen, Kai Xiong, Feiyuan Liang, Yanping Zhong, Xiong Qin, Nanchang Huang, Yuqi Fang, Bo Zhu, Jianwen Cheng, Qingjun Wei and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Lipopolysaccharide promotes rheumatoid arthritis by enhancing Wnt7b mediated macrophage-FLS communication.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chaotao Chen *Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed By the Province and Ministry, Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, NanningGuangxi, 530021, China.
Kai Xiong *Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed By the Province and Ministry, Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, NanningGuangxi, 530021, China.
Feiyuan Liang *Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed By the Province and Ministry, Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, NanningGuangxi, 530021, China.
Yanping Zhong *Life Sciences Institute, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Xiong QinDepartment of Bone and Soft Tissue Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China.
Nanchang HuangGuangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed By the Province and Ministry, Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, NanningGuangxi, 530021, China.
Yuqi FangGuangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed By the Province and Ministry, Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, NanningGuangxi, 530021, China.
Bo ZhuGuangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed By the Province and Ministry, Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, NanningGuangxi, 530021, China. zhubo@sr.gxmu.edu.cn.
Jianwen ChengDepartment of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China. chengjianwen@sr.gxmu.edu.cn.
Qingjun WeiDepartment of Orthopedics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530005, China. weiqingjungxnn@163.com.
Li ZhengGuangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed By the Province and Ministry, Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, NanningGuangxi, 530021, China. zhengli@gxmu.edu.cn.
Jinmin ZhaoGuangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed By the Province and Ministry, Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, NanningGuangxi, 530021, China.

Funding

the Guangxi Natural Science Foundation 2023GXNSFAA026002the Guangxi Scientific Research and Technological Development Foundation GuikeAB21220062the National Natural Science Foundation of China 82160418
6 · The paper itself

Abstract

backgroundOsteosarcoma (OS) is the most prevalent primary cancer of the bone. Metastasis and chemoresistance are the major obstacles to the improvement of OS prognosis, in which N

methodsMeRIP-seq and RNA-seq were conducted on OS and paired adjacent normal tissue samples, which determined CACNA1E as a key m

resultsCACNA1E exhibited notable m

conclusionsCollectively, our findings uncover that METTL3-mediated m

Indexed as

AdenosineBone NeoplasmsCalcium ChannelsCalcium SignalingDrug Resistance, NeoplasmOsteosarcomaWnt ProteinsAnimalsCell Line, TumorCell ProliferationDisease ProgressionEpitranscriptomeGene Expression Regulation, NeoplasticHumansMethotrexateMethyltransferasesAdenosineCalcium ChannelsMethotrexateMethyltransferasesMETTL3 protein, humanN-methyladenosineWNT7B protein, humanWnt ProteinsCa2+ signaling pathwayCACNA1EN6-methyladenosineOsteosarcomaResistanceWNT7B

Identifiers

PMID41549277
PMCPMC12951998

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.