ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Coagulation Markers and Myocardial Blush Grade in STEMI: Identifying Potential Predictors of Microvascular Reperfusion.
Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundMicrovascular reperfusion strongly influences prognosis after ST-elevation myocardial infarction (STEMI). While invasive indices are established, practical non-invasive biomarkers remain limited. This study evaluated whether coagulation markers correlate with myocardial blush grade (MBG)-an angiographic surrogate of tissue-level reperfusion-and could serve as non-invasive indicators of microvascular reperfusion.MethodsIn this single-center case-based study, 48 consecutive STEMI patients undergoing coronary angiography were enrolled. MBG was assessed by an experienced interventional cardiologist blinded to laboratory data. Blood was sampled after reperfusion for tissue plasminogen activator/plasminogen activator inhibitor-1 complex (tPA/PAI), prothrombin fragment 1 + 2 (F1 + 2), thrombin-antithrombin complex, and D-dimer. Associations between biomarkers and MBG (0-1 vs 2-3) were examined. Receiver operating characteristic (ROC) analysis determined cut-offs; multivariable models evaluated independence.ResultsMean age was 61.2 ± 11.8 years; 87.5% were male. Comorbidities included hypertension (47.9%) and hyperlipidemia (33.3%). MBG distribution was: MBG 3 (33.3%), MBG 1 (25.0%), MBG 0 (22.9%), MBG 2 (18.8%). Patients with MBG 0-1 had significantly higher tPA/PAI and F1 + 2 than those with MBG 2-3 (p = .003 and p < .001, respectively). Admission troponin and CK-MB were also higher in MBG 0-1 (p = .049 and p = .026). ROC analysis showed tPA/PAI < 9.4 μg/dL predicted MBG 2-3 (AUC = 0.752; 95% CI 0.606-0.865; sensitivity 72.0%, specificity 69.57%), and F1 + 2 ≤ 14 580 pmol/L predicted MBG 2-3 (AUC = 0.973; 95% CI 0.880-0.999; p < .001). Lower admission troponin and CK-MB also predicted MBG 2-3. In multivariable analysis, no biomarker remained independently associated with MBG.ConclusionsLower post-reperfusion tPA/PAI and F1 + 2 levels are associated with higher MBG (better microvascular reperfusion) in STEMI. Although not independently predictive, these readily measurable markers-particularly tPA/PAI-may complement reperfusion assessment when direct angiographic evaluation is unavailable. Larger, multicenter studies with standardized sampling are warranted to validate cut-offs and clinical utility.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.