Evidence map›Paper›PMID 41550129›Full record

ArticleInternational journal of cardiology. Cardiovascular risk and prevention2026

Prognostic value of the left atrioventricular coupling index for adverse cardiac outcomes in hypertrophic cardiomyopathy.

Sittinop Titichoatrattana, Ing-Orn Arunakul, Paisit Kosum, Aree Maitaothong, Em-On Puripun, Monravee Tumkosit, Yongkasem Vorasettakarnkij, Pairoj Chattranukulchai, Nonthikorn Theerasuwipakorn

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In one paragraph

Article in International journal of cardiology. Cardiovascular risk and prevention, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sittinop TitichoatrattanaDivision of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Ing-Orn ArunakulDivision of Cardiology, Department of Medicine, Faculty of Medicine, Pathum Thani, Thammasat University Hospital, Bangkok, Thailand.
Paisit KosumDivision of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand.
Aree MaitaothongDepartment of Radiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Em-On PuripunCardiac Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Monravee TumkositDepartment of Radiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Yongkasem VorasettakarnkijDivision of Hospital and Ambulatory Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Pairoj ChattranukulchaiDivision of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Nonthikorn TheerasuwipakornDivision of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hypertrophic cardiomyopathy (HCM) involves left atrial remodeling linked to adverse outcomes such as death, heart failure, and atrial fibrillation (AF). The left atrioventricular coupling index (LACI) reflects atrial-ventricular interaction, but its prognostic role in HCM is unclear. The objective of this study is to evaluate the prognostic value of cardiac magnetic resonance imaging (CMR)-derived LACI and identify optimal cut-offs for predicting adverse outcomes in HCM. Methods: This retrospective cohort study included HCM patients who underwent CMR with at least 1 year of follow-up. LACI was calculated as the ratio of left atrial to left ventricular end-diastolic volume. Associations between LACI and outcomes were analyzed using Cox regression. The primary outcome was a composite endpoint of all-cause death and hospitalization for heart failure (HHF). Secondary outcomes included all-cause death, HHF, and new-onset AF. Receiver operating characteristic (ROC) analysis determined optimal LACI cut-offs. Results: Among 183 patients (median age 61 years; 59 % male) followed for 4.2 years, 53 (29 %) reached the primary endpoint. Elevated LACI independently predicted the primary composite endpoint (≥0.41: aHR 2.24, 95 %CI: 1.19, 4.24, p = 0.013), HHF (≥0.44: aHR 4.54, 95 %CI: 1.69, 12.19, p = 0.003), and new-onset AF (≥0.44: aHR 3.06, 95 %CI: 1.26, 7.43, p = 0.003) but not all-cause death. Conclusion: CMR-derived LACI independently predicted adverse outcomes in HCM, offering a reproducible marker for improved risk stratification.

Indexed as

All-cause mortalityAtrial fibrillationHeart failureHypertrophic cardiomyopathyLeft atrioventricular coupling index

Identifiers

PMID41550129
PMCPMC12811596

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.