ArticleMetabolism open2026
Cholecystectomy with jejunoileal bypass ameliorates diabetic metabolism in mice with type 2 diabetes through modulation of FXR and TGR5 signaling.
Article in Metabolism open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objectives: Our aim was to investigate the improvement in glucose and lipid profiles and the mechanism involving bile acid receptors FXR and TGR5 following cholecystectomy with jejunoileal bypass(CJB) in mice with type 2 diabetes mellitus (T2DM). Methods: Twenty male mice with T2DM were randomly assigned to CJB and sham groups. We analyzed fasting blood glucose (FBG), insulin, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), free fatty acids (FFA), glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), and total bile acids (TBA) levels. Expression levels of the farnesoid X receptor (FXR) and G protein-coupled bile acid receptor (TGR5) in liver, muscle, and adipose tissue were assessed post-sacrifice. Results: Despite pair-feeding, the CJB group exhibited lower body weights than the sham group at 24 weeks post-surgery ( Conclusions: In mice with T2DM, cholecystectomy with jejunoileal bypass modulates BA-FXR/TGR5 signaling and is associated with metabolic improvement.
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