ArticleTransboundary and emerging diseases2026
Novel Duck Orthoreovirus Induces Ferroptosis in HD11 Cells by Hijacking Cellular Iron Metabolism and Promoting Iron Accumulation.
Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Novel duck orthoreovirus (NDRV) infection induces severe splenic necrosis in ducks, resulting in a cascade of detrimental consequences, including immunosuppression, secondary infections, and diminished vaccine efficacy. Avian orthoreovirus (ARV) exhibits high tropism for macrophages, with splenic macrophages being identified as the primary target cells of NDRV. Although ferroptosis has been implicated in this pathological process, the molecular mechanism underlying NDRV-induced cellular damage remains poorly elucidated. In this study, an in vitro model of NDRV infection was established using HD11 cells to systematically investigate its effect on ferroptosis and the associated mechanisms. Our results indicate that NDRV infection triggers ferroptosis and markedly elevates intracellular Fe
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