ArticlebioRxiv : the preprint server for biology2025
PtdIns(3,5)P
Jay Xiaojun Tan, Bo Lv, Jie Li, Tuo Li, Fenghe Du, Xiang Chen, Xuewu Zhang, Xiao-Chen Bai, Zhijian J Chen
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Jay Xiaojun TanAging Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15219.ORCID 0000-0003-3300-2240 Bo LvAging Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15219.
Jie LiDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Tuo LiDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Fenghe DuDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Xiang ChenDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Xuewu ZhangDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Xiao-Chen BaiDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Zhijian J ChenDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Funding
Novel regulatory mechanisms and agonists of STINGR01CA273595 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Xiaochen Bai, CHUO CHEN · 2023 to 2026
$2.7MBiochemical Dissection of the RIG-I Antiviral PathwayR01AI093967 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, ZHIJIAN J · 2011 to 2015
$2.0MLysosomal quality control through lipid remodelingR35GM150506 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Xiaojun Tan · 2023 to 2026
$1.8MNovel endogenous and engineered activators of STING: from mechanisms to cancer therapyR01CA299257 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Xiaochen Bai, Zhijian J Chen · 2025 to 2026
$1.3MNCI NIH HHS R01 CA273595NCI NIH HHS R01 CA299257NIAID NIH HHS R01 AI093967NIGMS NIH HHS R35 GM150506
6 · The paper itselfAbstract
Cytosolic DNA exposure triggers innate immune responses through cyclic GMP-AMP (cGAMP) synthase (cGAS)
Identifiers
PMID41550346
PMCPMC12809434
What Socratic holds
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