Evidence map›Paper›PMID 41550599›Full record

ArticleJournal of ginseng research2026

Renoprotective mechanisms of bioconverted wild-simulated ginseng: mitigating oxidative stress, inflammation, and apoptosis to protect against ischemic renal injury via Nrf2/HO-1/NF-κB/caspase-3 signaling.

Ye Ji Kim, Md Shiblee Sadik Sabuj, Myung-Kon Kim, Joonseok Lee, Ryunhee Kim, Seung Hyun Lee, Jin Min Oh, Hyeon Gyeong Ro, In-Shik Kim, Dongchoon Ahn and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ginseng research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ye Ji KimCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, Republic of Korea.
Md Shiblee Sadik SabujCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, Republic of Korea.
Myung-Kon KimDepartment of Food Science and Technology, Jeonbuk National University, Jeonju, 54896, Republic of Korea.
Joonseok LeeCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, Republic of Korea.
Ryunhee KimCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, Republic of Korea.
Seung Hyun LeeCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, Republic of Korea.
Jin Min OhCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, Republic of Korea.
Hyeon Gyeong RoCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, Republic of Korea.
In-Shik KimCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, Republic of Korea.
Dongchoon AhnCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, Republic of Korea.
Md Rashedunnabi AkandaDepartment of Pharmacology and Toxicology, Sylhet Agricultural University, Sylhet, 3100, Bangladesh.
Hyun-Jin TaeCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, Republic of Korea.
Byung-Yong ParkCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ischemia-reperfusion (I/R) induced acute kidney injury (AKI) is a severe condition linked to higher morbidity and mortality. Methods: C57BL/6 mice underwent bilateral renal pedicle clamping via a dorsal approach for 30 min to induce ischemia, followed by clamp release and 24 h of reperfusion. Blood and kidney samples were collected at the end of the reperfusion period. Sham-operated mice underwent identical procedures without vascular clamping. Additionally, hydrogen peroxide (H Results: The effects of each extract were evaluated. Expression of antioxidant, inflammatory, and apoptotic factors was confirmed using western blotting, immunohistochemistry, and TUNEL assays. Both extracts improved the survival of H Conclusion: BPG and BWG remarkably ameliorated I/R-induced AKI through modulation of Nrf2/HO-1/NF-κB/Caspase-3 signaling pathway, with BWG exhibiting more substantial renoprotective effects.

Indexed as

Bioconverted wild-simulated ginsengIschemic renal injuryNrf2/HO-1/NF-κB/Caspase-3 signalingOxidative stressRenoprotection

Identifiers

PMID41550599
PMCPMC12805545

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.