Evidence map›Paper›PMID 41550752›Full record

ArticleiScience2026

MCD enzyme deficiency drives early mortality and multiorgan metabolic disruption in Dahl salt-sensitive rats.

Olha Kravtsova, Yifan Tan, Vladislav Levchenko, Elina Kovalenko, Ratnakar Tiwari, Adrian Zietara, Ruslan Bohovyk, Lashodya V Dissanayake, Thanh Trung Van, Thomas E Sharp and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Olha KravtsovaDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.
Yifan TanDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Vladislav LevchenkoDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.
Elina KovalenkoDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Ratnakar TiwariDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.
Adrian ZietaraDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.
Ruslan BohovykDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.
Lashodya V DissanayakeDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.
Thanh Trung VanDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.
Thomas E SharpDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.
Aron M GeurtsDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Oleg PalyginDivision of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Markus M RinschenDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Alexander StaruschenkoDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.

Funding

Training in Research on Vascular Inflammation and InjuryT32HL160529 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · 2022 to 2025
$688k
Sexual dimorphisms and role of the cGAS-STING pathway in diabetic nephropathyR01DK135644 · UNIVERSITY OF SOUTH FLORIDA · 2025 to 2025
$513k
Renal diabetic complications mediated by the PAR1 signaling in podocytesR01DK129227 · UNIVERSITY OF SOUTH FLORIDA · 2025 to 2025
$326k
BLRD VA I01 BX004024NHLBI NIH HHS T32 HL160529NIDDK NIH HHS R01 DK129227NIDDK NIH HHS R01 DK135644
6 · The paper itself

Abstract

Malonyl-CoA decarboxylase (MCD), encoded by

Indexed as

MetabolomicsProteomics

Identifiers

PMID41550752
PMCPMC12808911

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.