Evidence map›Paper›PMID 41550763›Full record

ArticleiScience2026

Association between biological aging and coronary heart disease: A secondary analysis of two observational studies.

Shiying Lin, Minghuan Liu, Xinyue Lu, Yang Song, Huangyuan Li, Feng Hu, Lin Fan, Xiaoxu Xie, Shaowei Lin, Siying Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Application of biological age for cardiovascular risk prediction in a community-based Chinese cohort].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shiying LinDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, China.
Minghuan LiuDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, China.
Xinyue LuDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, China.
Yang SongDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, China.
Huangyuan LiDepartment of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, China.
Feng HuDepartment of Cardiology, Fujian Medical University Union Hospital, Fujian Cardiovascular Medical Center, Fujian Institute of Coronary Artery Disease, Fujian Cardiovascular Research Center, Fuzhou 350001, China.
Lin FanDepartment of Cardiology, Fujian Medical University Union Hospital, Fujian Cardiovascular Medical Center, Fujian Institute of Coronary Artery Disease, Fujian Cardiovascular Research Center, Fuzhou 350001, China.
Xiaoxu XieDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, China.
Shaowei LinDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, China.
Siying WuDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While aging is a well-established contributor to cardiovascular disease, the specific relation between biological aging-as assessed by PhenoAge and PhenoAge acceleration-and the risk of coronary heart disease (CHD) requires further evidence to elucidate. This study conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES), alongside both cross-sectional and prospective analyses using data from the UK Biobank, to investigate the association between biological aging and CHD risk across two large cohorts. The results indicated that each unit increase in PhenoAge and PhenoAge acceleration was significantly associated with a higher risk of CHD. Compared to individuals without accelerated aging, those experiencing accelerated aging face a significantly higher risk. These findings suggest that PhenoAge and its acceleration are significant risk factors for CHD development. Moreover, surrogate markers of biological aging may serve as valuable tools for both the primary and secondary prevention of CHD.

Indexed as

Human physiologyPublic health

Identifiers

PMID41550763
PMCPMC12808888

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.