ArticleRSC advances2026
Development of novel salicylic acid derivatives with dual anti-inflammatory and anti-arthritic potentials: synthesis,
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development of anti-inflammatory agents targeting COX and 5-LOX, along with anti-arthritic agents, is a crucial approach in drug discovery. In this study, we designed and synthesized novel azomethine salicylic acid derivatives 2-9 by condensing 4-aminosalicylic acid with various formyl or ketone groups attached to benzylidene or heterocyclic cores. The reaction was carried out under reflux conditions utilizing acetic acid as the solvent. Initially, target prediction was performed, and the results indicated that these derivatives have potential as inhibitors of enzymes, proteases, and kinases. Furthermore, the designed derivatives underwent evaluation to assess their anti-inflammatory activity through COX-1, COX-2, and 5-LOX, as well as their anti-arthritic properties. Three derivatives 2, 4, and 9 demonstrated the most significant activity, with IC
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.