ReviewFrontiers in immunology2025
Recent advances on Hippo-YAP pathway in skin diseases.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Hippo Pathway-YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets.MedComm · 2026Review
- A PIEZO-Gated Mechanotransduction Timing Window Governs Scar Commitment in Wound Healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Hippo-YAP pathway is a critical signaling cascade that regulates essential cellular processes, including proliferation, inflammation, and the fate of cancer cells. Recent studies have increasingly highlighted the significant role of the Hippo-YAP pathway in the pathogenesis and progression of various skin diseases. This review aims to summarize the latest advancements related to the Hippo-YAP pathway in skin disorders, exploring its regulatory mechanisms in the context of skin tumors, inflammatory skin diseases, skin aging, wound healing and skin development. Furthermore, this review will analyze the current challenges and knowledge gaps within this field and propose future directions and potential therapeutics targeting the Hippo-YAP pathway to improve treatment outcomes for skin diseases. This review also acknowledges several limitations, including the heterogeneity of existing studies, variations in experimental models, and the scarcity of clinical evidence directly linking Hippo-YAP dysregulation to specific skin diseases. These factors highlight the need for more standardized and clinically oriented research in the future.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.