Evidence map›Paper›PMID 41550931›Full record

ArticleFrontiers in immunology2025

Case Report: Possible C3 nephritic factor-driven complement-mediated severe hemolytic anemia and acute kidney injury in a child with

Steffen Ullitz Thorsen, Anne Todsen Hansen, Hans Jakob Hartling, Hanne Vibeke Marquart, Line Borgwardt, Mira Marie Laustsen, Lillemor Skattum, Alex Christian Yde Nielsen, Line Thousig Sehested, Hanne Nørgaard and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Steffen Ullitz ThorsenDepartment of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Anne Todsen HansenDepartment of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Hans Jakob HartlingDepartment of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Hanne Vibeke MarquartDepartment of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Line BorgwardtCenter for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Mira Marie LaustsenCenter for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Lillemor SkattumClinical Immunology and Transfusion Medicine, Lund University Hospital, Lund, Sweden.
Alex Christian Yde NielsenDepartment of Clinical Microbiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Line Thousig SehestedDepartment of Pediatrics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Hanne NørgaardDepartment of Pediatrics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Morten Hanefeld DziegielDepartment of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Ida Maria SchmidtDepartment of Pediatrics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overactivation of the complement system can cause life-threatening intravascular hemolysis, acute kidney injury (AKI), and multi-organ failure. Expanding the spectrum of rarer triggers of complement dysregulation that may cause severe hemolysis is essential for timely diagnosis and treatment. We report the case of a three-year-old boy admitted with macroscopic hematuria and jaundice. The patient tested positive for

Indexed as

Acute Kidney InjuryAnemia, HemolyticAtypical Hemolytic Uremic SyndromeBordetella parapertussisComplement C3 Nephritic FactorAntibodies, Monoclonal, HumanizedChild, PreschoolHemolysisHumansMaleAntibodies, Monoclonal, HumanizedComplement C3 Nephritic Factoreculizumabacute kidney injuryalternative complement pathwayatypical hemolytic syndromeC3 nephritic factorhemolysispediatrics

Identifiers

PMID41550931
PMCPMC12808469

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.