ArticleComprehensive psychoneuroendocrinology2026
Exploring the mediating roles of diet and physical activity in the association between different obesity phenotypes and risk of depression: A cox survival analysis approach.
Article in Comprehensive psychoneuroendocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Although obesity has been linked to an increased risk of depression, the risk associated with different obesity phenotypes remain unclear, as does the role of lifestyle behaviors. Participants from the UK Biobank who were free of depression at the baseline and had complete data on body composition and metabolism-related measures were selected and followed up. Multivariable Cox models were employed to assess the risk of developing depression according to obesity phenotypes. Mediation analyses were conducted to evaluate the potential mediating effects of diet and physical activity in this association. Among 391,781 participants, a total of 20,027 incident depression was recorded after a median follow-up period of 13.39 years. Our study revealed that different obesity phenotypes increased the risk of depression to varying degrees. Compared with healthy non-obese individuals, those with BMI ≥30 kg/m
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