Evidence map›Paper›PMID 41551014›Full record

ReviewChinese medical journal pulmonary and critical care medicine2025

Aging and lung diseases: Unraveling mechanisms and therapeutic targets.

Yanan Zhou, Gaoying Chen, Xiang Li, Xiaohe Li, Zeqiang Lin, Li Liu, Dan Pu, Jiyuan Chen, Yuqin Chen, Ziying Lin and 9 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chinese medical journal pulmonary and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Structural and cellular mechanisms of mucus plugging in the larger airways.Chinese medical journal pulmonary and critical care medicine · 2026
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yanan ZhouShanghai Key Laboratory of Lung Inflammation and Injury, Shanghai Respiratory Research Institute, Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Gaoying ChenDepartment of Pharmacy, Center for Regeneration and Aging Medicine, The Fourth Affiliated Hospital of School of Medicine and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang 322000, China.
Xiang LiState Key Laboratory of Respiratory Diseases, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Guangdong Key Laboratory of Vascular Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510030, China.
Xiaohe LiState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, College of Pharmacy, Nankai University, Tianjin 300350, China.
Zeqiang LinState Key Laboratory of Respiratory Diseases, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Guangdong Key Laboratory of Vascular Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510030, China.
Li LiuDepartment of Respiratory and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Dan PuLung Cancer Centre/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Jiyuan ChenDepartment of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510510, China.
Yuqin ChenState Key Laboratory of Respiratory Diseases, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Guangdong Key Laboratory of Vascular Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510030, China.
Ziying LinState Key Laboratory of Respiratory Diseases, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Guangdong Key Laboratory of Vascular Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510030, China.
Zili ZhangState Key Laboratory of Respiratory Diseases, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Guangdong Key Laboratory of Vascular Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510030, China.
Lingling ZhuLung Cancer Centre/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Wenju LuState Key Laboratory of Respiratory Diseases, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Guangdong Key Laboratory of Vascular Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510030, China.
Wen NingState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, College of Pharmacy, Nankai University, Tianjin 300350, China.
Jian WangState Key Laboratory of Respiratory Diseases, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Guangdong Key Laboratory of Vascular Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510030, China.
Songmin YingDepartment of Pharmacy, Center for Regeneration and Aging Medicine, The Fourth Affiliated Hospital of School of Medicine and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang 322000, China.
Jing ZhangDepartment of Respiratory and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Qinghua ZhouLung Cancer Centre/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Yuanlin SongShanghai Key Laboratory of Lung Inflammation and Injury, Shanghai Respiratory Research Institute, Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As life expectancy increases globally, the prevalence of various age-related diseases among the elderly is rising. Advancing age is associated with both the incidence and mortality of a variety of respiratory diseases; however, the specific correlations and underlying mechanisms remain incompletely understood. This review summarizes changes in lung physiology and structure, as well as the biology of immune system cells, in relation to idiopathic pulmonary fibrosis, acute respiratory distress syndrome, pulmonary hypertension, asthma, chronic obstructive pulmonary disease, and lung cancer. It also offers a comprehensive discussion of the relationships between these lung diseases and aging, along with potential mechanistic insights. Finally, the review underscores that the association between aging and lung disease supports the development of personalized intervention strategies, with particular consideration of disease heterogeneity. Future research should prioritize the identification and validation of robust aging biomarkers and aging-related disease phenotypes.

Indexed as

Acute respiratory distress syndromeAsthmaCellular senescenceChronic obstructive pulmonary diseaseIdiopathic pulmonary fibrosisImmune senescenceLung agingLung cancerPulmonary hypertensionTreatment strategy

Identifiers

PMID41551014
PMCPMC12805403

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.