Evidence map›Paper›PMID 41551453›Full record

ArticlePeerJ2026

Determinants of subclinical leprosy among household contacts in Indonesia: serological and socio-demographic factors.

Khariri Khariri, Sunarno Sunarno, Novaria Sari Dewi Panjaitan, Putu Yuliandari, Sarwo Handayani, Rita Marleta Dewi, Nastiti Intan Permata Sari, Fitriana Fitriana, Agriani Dini Pasiana, Ina Kusrini and 1 more

Abstract read
In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Khariri KhaririCenter for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia.
Sunarno SunarnoCenter for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia.
Novaria Sari Dewi PanjaitanCenter for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia.
Putu YuliandariCenter for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia.ORCID 0000-0002-7322-0915
Sarwo HandayaniCenter for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia.
Rita Marleta DewiCenter for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia.
Nastiti Intan Permata SariCenter for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia.
Fitriana FitrianaCenter for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia.
Agriani Dini PasianaCenter for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia.ORCID 0000-0003-0597-4464
Ina KusriniDirectorate of Evaluation Policy Research and Innovation, National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia.
Edwin Nugroho NjotoFaculty of Medicine and Health, Institut Teknologi Sepuluh Nopember, Surabaya, East Java, Indonesia.ORCID 0000-0001-6903-3407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Leprosy remains a public health challenge in Indonesia, which ranks third globally after India and Brazil. Subclinical infection among household contacts contributes to ongoing transmission, as individuals infected with Methods: A cross-sectional study was conducted in 2020 among 320 household contacts of confirmed leprosy index cases recruited through purposive sampling. Anti-Phenolic Glycolipid-1 (PGL-1) IgM antibodies were detected using an in-house enzyme-linked immunosorbent assay (ELISA). Bivariate analysis using Chi-square and Results: Overall, 43.8% of household contacts were seropositive for anti-PGL-1 IgM antibodies. Multivariate analysis revealed that a history of Bacille Calmette-Guerin (BCG) vaccination was associated with significantly lower odds of seropositivity (adjusted OR = 0.514; 95% CI [0.291-0.907]; Conclusion: BCG vaccination status and visible BCG scars were key determinants of anti-PGL-1 seropositivity, suggesting complex interactions between vaccination, immune response, and exposure to

Indexed as

Asymptomatic InfectionsLeprosyMycobacterium lepraeAdolescentAdultAntibodies, BacterialAntigens, BacterialBCG VaccineChildChild, PreschoolCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFamily CharacteristicsFemaleGlycolipidsHumansAntibodies, BacterialAntigens, BacterialBCG VaccineGlycolipidsImmunoglobulin Mphenolic glycolipid I, Mycobacterium lepraeBCG vaccinationHousehold contactsIndonesiaMycobacterium lepraePreventive medicineSeroepidemiologySubclinical leprosy

Identifiers

PMID41551453
PMCPMC12805909

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.