ArticleFrontiers in microbiology2025
Long-term effects of altitude on changes in intestinal flora in a young and middle-aged population: a longitudinal analysis before and after 6 months of entry to high altitude.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Effects of High-Altitude Environments on Gut Microbiota and Their Mechanisms in Immune Regulation and High-Altitude Adaptation.International journal of molecular sciences · 2026Review
- Gut-heart axis at high altitude: a dynamic mediator from hypoxic dysbiosis to adaptive cardioprotection.Frontiers in microbiology · 2026Review
- Microbiota-gut-brain axis imbalance: a promising therapeutic target for preserving brain health in high-altitude environment.Frontiers in neuroscience · 2026Review
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7 authors.
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Abstract
Introduction: The low oxygen environment of high altitude predisposes to imbalances in gut flora and changes in metabolites that can affect metabolic health. The relationship between gut flora and the health of sedentary populations at high altitude has been extensively studied. However, the dynamic changes of gut flora and its metabolomics after entering high altitude and the long-term effects on the health of young and middle-aged people have not been studied enough. This study aims to investigate the patterns of gut microbiota and metabolomics changes in middle-aged and young adults during the week preceding ascent to 4,500 m above sea level and within the 6 months following high-altitude exposure. Methods: A total of 70 healthy young and middle-aged people were collected from November 2023 to June 2024 from an altitude of about 1,600 to 4,500 m, and their stool samples were collected. 16S rRNA sequencing and liquid-liquid-mass spectrometry (LC-MS/MS) were used to detect the changes in the composition of the gut microorganisms and the differential metabolites of the intestinal tract in the young and middle-aged people before and after they entered the altitude, and the changes in the abundance and composition of the gut flora and their metabolomics were analyzed. Abundance and composition and the changes in their metabolomics. Results: The results showed that the largest differences in the abundance of intestinal microorganisms at the phylum and genus levels were Firmicutes and Discussion: In conclusion, significant changes in the diversity, abundance, composition and differential metabolites of the intestinal gut flora occurred before and after entering high altitude in young and middle-aged populations, which may be important for the adaptation of young and middle-aged populations in the plateau environment.
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