ArticleAmerican journal of translational research2025
Study on repair of periodontal bone defect in rats with PCL-PEG electrospun nanofibers combined with amniotic homogenate supernatant.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesGiven the lack of effective treatments for periodontal bone tissue regeneration, this study aimed to evaluate the efficacy of Polycaprolactone-Polyethylene glycol (PCL-PEG) electrospun nanofibers combined with amniotic homogenate supernatant (AMH) on periodontal bone repair.
methodsPCL-PEG electrospun nanofibers were prepared by electrospinning and characterized. In vitro, hPDLSCs were divided into control, AMH, PCL-PEG, and PCL-PEG+AMH groups, and real-time polymerase chain reaction (PCR) and western blot assays were used to detect osteogenic genes and proteins (Alkaline Phosphatase (ALP), Collagen Type 1 (COL1), Runt-Related Transcription Factor 2 (RUNX2)) to evaluate cell proliferation and osteogenic differentiation. In vivo, a rat periodontal bone defect model was established. The rats were divided into three groups: a blank control group, a PCL-PEG + PDLSCs group, and a PCL-PEG+AMH + PDLSCs group, and hematoxylin and eosin (HE) staining and micro-computed tomography (Micro-CT) analyzed new bone formation after 4 weeks.
resultsPCL-PEG nanofibers had a "fishnet" 3D structure, good hydrophilicity, mechanical strength, and biocompatibility. Both in vitro and in vivo, the PCL-PEG+AMH group exhibited the strongest osteogenic potential and the highest amount of new bone formation.
conclusionsThe combination of electrospun nanofibers and AMH can boost periodontal stem cell functions, enhancing alveolar bone repair and providing a new type of support for periodontal bone tissue regeneration.
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