ArticleAmerican journal of translational research2025
Correlation between oxidative stress level and clinical outcome in rotator cuff injury patients.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the relationship between oxidative stress (OS) and clinical outcome in patients with rotator cuff injury (RCI).
methodsEighty-two surgically treated RCI patients (May 2022-February 2025) were enrolled in this retrospective study. All participants underwent arthroscopic rotator cuff repair and were further grouped into a good prognosis group (n=39) or a poor prognosis group (n=43) based on the University of California, Los Angeles (UCLA) Shoulder Rating Scale (UCLA ≥29 vs. UCLA <29). Relevant clinical details like age, sex, tear area, disease duration, injury pattern, and UCLA scores, were collected. Serum samples were tested pre- and postoperatively for the quantification of OS biomarkers: reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx). Pearson correlation analysis was used to evaluate the association between OS biomarkers and UCLA scores. Receiver operating characteristic (ROC) curve analysis was used to assess their predictive value for clinical outcomes. Prognostic determinants were identified using univariate and multivariate logistic regression analyses.
resultsROS and MDA concentrations were markedly elevated in poor-prognosis patients compared to favorable-prognosis individuals, whereas SOD and GPx activities were reduced. Surgical intervention significantly elevated the levels of SOD and GPx, and reduced the levels of ROS and MDA. Correlation analyses linked higher UCLA scores to elevated ROS/MDA levels and reduced SOD/GPx activity. ROC curve analysis showed that the predictive accuracy (area under the curve [AUC]) for individual OS biomarkers ranged from 0.750-0.810, which was markedly improved (AUC=0.939) when used in combination. Univariate and multivariate logistic regression analysis further identified ROS, MDA, SOD, and GPx as independent factors influencing clinical prognoses in RCI patients.
conclusionOS levels can serve as a key determinant of clinical outcome in RCI patients.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.