ArticleAmerican journal of translational research2025
Difference in the ratio of low-density lipoprotein to lymphocytes between acute exacerbation of and stable phase of chronic obstructive pulmonary disease patients.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo examine difference in the low-density lipoprotein cholesterol/lymphocyte (LDL-C/LYM) ratio between the acute exacerbation and stable phases of chronic obstructive pulmonary disease (COPD) and assess its diagnostic and prognostic value.
methodsA total of 196 hospitalized COPD patients were retrospectively analyzed, including 96 in the acute exacerbation phase and 100 in the stable phase. Demographics, inflammatory markers [C-reactive protein (CRP), interleukin-6 (IL-6), white blood cell count (WBC), monocyte percentage (MO%)], pulmonary function indices [percentage of predicted forced expiratory volume in one second (FEV
resultsLDL-C/LYM ratio was significantly higher during acute exacerbation (P < 0.001), positively correlated with CRP, IL-6, WBC, and MO% (r = 0.404-0.606), and negatively with FEV
conclusionThe LDL-C/LYM ratio is elevated during COPD exacerbations and reflects inflammation and lung function decline, serving as a simple biomarker for diagnosis and prognosis.
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