Evidence map›Paper›PMID 41552434›Full record

ArticleACS omega2026

Restoration of the Y220C p53 Full-Length Mutant by PK11000: a Molecular Dynamics Study of an Intrinsically Disordered Protein.

Sean Stetson, Fernando Caballero Mancía, Kelly M Thayer

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sean StetsonDepartment of Computer Science, Wesleyan University Middletown, Connecticut 06457, United States.ORCID https://orcid.org/0009-0007-9759-5977
Fernando Caballero MancíaDepartment of Computer Science, Wesleyan University Middletown, Connecticut 06457, United States.
Kelly M ThayerDepartment of Computer Science, Wesleyan University Middletown, Connecticut 06457, United States.ORCID https://orcid.org/0000-0001-7437-9517

Funding

Ensemble Networks for Allosteric Drug DesignR15GM128102 · NIGMS · WESLEYAN UNIVERSITY · PI THAYER, KELLY MARIE · 2018 to 2021
$976k
NIGMS NIH HHS R15 GM128102
6 · The paper itself

Abstract

The tumor suppressor protein p53 plays a key role in cellular homeostasis, with its dysfunction linked to over half of all cases of human cancer. The Y220C mutation in the DNA-binding domain (DBD) destabilizes p53, compromising its function. The most well-studied case of Y220C p53 rescue via a small molecule, PK11000, has been shown to restore stability and reinstate activity both

Identifiers

PMID41552434
PMCPMC12809809

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.