Observational studyCNS neuroscience & therapeutics2026
Structural Connectivity Disruption and Structural-Functional Decoupling in Working Memory Networks Across Pre-Dialysis and Maintenance Hemodialysis End-Stage Renal Disease Patients.
Observational study in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03961724 (Combination of Neuroimaging and Metabolomics of Brain Impairment in Patients With End-stage Renal Disease), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combination of Neuroimaging and Metabolomics of Brain Impairment in Patients With End-stage Renal Disease: a Multi-center Prospective Cohort Study
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
aimsEnd-stage renal disease (ESRD) is associated with working memory (WM) impairment. We assessed how structural connectivity (SC), functional connectivity (FC), and structural-functional coupling (SFC) differ between pre-dialysis ESRD (ESRDp), maintenance hemodialysis ESRD (ESRDm), and healthy controls (HCs), and how these changes relate to serum markers and WM performance.
methods29 ESRDp, 29 ESRDm, and 46 HCs completed 0-, 1-, and 2-back tasks, diffusion MRI, and fMRI. WM nodes were defined by overlaying a meta-analytic map with the Harvard-Oxford atlas. SC, FC, and regional SFC were computed among WM-related regions. Group differences, correlations with serum markers, and mediation models were examined.
resultsESRDp showed markedly lower n-back accuracy, longer reaction time (RT), reduced frontoparietal SC, and widespread SFC reductions compared with ESRDm and HCs, whereas ESRDm exhibited near-normal WM performance and partially restored SC/SFC. Elevated urea and lower sodium in ESRDp were associated with weaker SC and altered SFC, which related to poorer accuracy and slower RT; SC and SFC significantly mediated these associations.
conclusionESRDp is characterized by disruption and decoupling of WM networks, while ESRDm is associated with partial network normalization. WM-related SC and SFC combined with serum markers may help identify cognitive vulnerability in ESRD.
trial registrationClinicalTrials.gov identifier: NCT03961724.
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