In one paragraphArticle in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
22 authors.
Galyna Pryymachuk *Institute of Anatomy Brandenburg Medical School Theodor Fontane Neuruppin Germany.ORCID 0000-0002-6971-2802 Viktor V Velyanov *Department of Physiology and Pathophysiology Medical University-Varna Varna Bulgaria.
Nikola R LazarovDepartment of Physiology and Pathophysiology Medical University-Varna Varna Bulgaria.ORCID 0009-0004-8456-9583 Simon NesteleInstitute of Physiology Brandenburg Medical School Theodor Fontane Germany.
Mechthild M SchroeterInstitute of Cellular and Molecular Physiology, Center of Physiology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.ORCID 0000-0003-0184-1146 Sarah JelinekInstitute of Physiology Brandenburg Medical School Theodor Fontane Germany.
Nadin PiekarekExperimental Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.ORCID 0000-0002-2954-0145 Maria BustInstitute of Systems Physiology, Center of Physiology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.
Nikolai T EvtimovVascular Biology Research Group-Varna, (RenEVA) Medical University-Varna Varna Bulgaria.
Thomas EnzmannUrology and Children Urology Clinic, Brandenburg Medical School Theodor Fontane Theodor Fontane Germany.
Hendrik BorgmannUrology and Children Urology Clinic, Brandenburg Medical School Theodor Fontane Theodor Fontane Germany.ORCID 0000-0002-3955-564X Gerhard SengleDepartment of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.ORCID 0000-0003-3932-1242 Jürgen HeschelerInstitute of Neurophysiology, Center of Physiology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.
Tatiana KorotkovaInstitute of Systems Physiology, Center of Physiology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.ORCID 0000-0001-7964-9838 Hristo GagovDepartment of Animal and Human Physiology, Faculty of Biology Sofia University "St. Kliment Ohridski," Sofia Bulgaria.
Vladimir TodorovInstitute of Physiology and Pathophysiology, Biomedical Center for Education and Research (ZBAF) Witten/Herdecke University Witten Germany.ORCID 0000-0002-7011-8130 Kamelya BratoevaDepartment of Physiology and Pathophysiology Medical University-Varna Varna Bulgaria.ORCID 0000-0002-6235-3384 Anton B TonchevVascular Biology Research Group-Varna, (RenEVA) Medical University-Varna Varna Bulgaria.
Gabriele PfitzerInstitute of Systems Physiology, Center of Physiology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.ORCID 0000-0002-8684-8947 Lubomir T LubomirovVascular Biology Research Group-Varna, (RenEVA) Medical University-Varna Varna Bulgaria.ORCID 0000-0002-3854-7170 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundCaldesmon is an actomyosin-tropomyosin-binding protein with pleiotropic functions that generally acts as an inhibitor of actomyosin ATPase activity. This study aims to explore the role of caldesmon in regulation of preglomerular vascular tone.
methodsExpression of caldesmon, myosin light chain, and α-smooth muscle actin was assessed by western blot of interlobar arteries (IAs) from young and old mice or human renal arteries from patients who underwent nephrectomy or tumor enucleation. IAs were obtained from wild-type or heterozygous mice, carrying a mutant allele that ablates both caldesmon isoforms (caldesmon
resultsCaldesmon was expressed in all preglomerular vessels of mice and humans. In caldesmon
conclusionsThis study provides cumulative evidence that caldesmon is a marker of age and inflammation-related changes in preglomerular vascular function. Our work supports the view that in the renal vasculature, caldesmon expression is age dependent and determines its sensitivity to the RhoA-associated protein kinase/p21-activated protein kinase 1 regulatory pathway.
Indexed as
Calmodulin-Binding ProteinsRenal ArteryVasoconstrictionVasodilationActinsAge FactorsAgingAnimalsFemaleHumansMaleMiceMice, Inbred C57BLMyosin Light ChainsVasoconstrictor AgentsActinsCalmodulin-Binding ProteinsMyosin Light ChainsVasoconstrictor Agentsagingcaldesmon mutationpreglomerular vasculature tone
Identifiers
PMID41553092
PMCPMC12919474
What Socratic holds
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