ArticleJournal of the American Heart Association2026
Island Sign on Computed Tomography Is Associated With Cerebral Amyloid Angiopathy in Patients With Intracerebral Hemorrhage.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
backgroundIrregular hematoma border is a prominent yet understudied imaging feature of cerebral amyloid angiopathy (CAA)-related intracerebral hemorrhage (ICH). We investigated whether island sign and irregular shape could be an additional imaging marker of CAA-related ICH.
methodsThis cross-sectional analysis included a prospective cohort of consecutive patients with supratentorial ICH with both computed tomography and magnetic resonance imaging. Presence of island sign and irregular shape on computed tomography was assessed blinded to clinical and magnetic resonance imaging data. The primary outcome was probable CAA by Boston criteria v2.0. Multivariable logistic regression analysis was conducted to evaluate associations of island sign or irregular shape with probable CAA. Diagnostic accuracy of the simplified Edinburgh criteria before and after incorporating island sign or irregular shape was compared using area under the receiver operating characteristics curve and DeLong test.
resultsAmong 488 patients, 51 (10.5%) patients had CAA-ICH. Island sign (39.2% versus 4.1%,
conclusionsIsland sign is associated with magnetic resonance imaging-based diagnosis of CAA and improves the diagnostic accuracy of the simplified Edinburgh criteria, aiding in accurate identification of CAA-related ICH.
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