Evidence map›Paper›PMID 41553195›Full record

ArticleASN neuro2026

Loss of Fatty Acid Oxidation by Neural Stem and Progenitor Cells Increases Proliferation but Does Not Improve Long-Term Neurogenesis After Mild Traumatic Brain Injury.

Javier Allende Labastida, Regina F Fernandez, Tiffany Chu, Noelle Puleo, Maria Shishikura, Michael J Wolfgang, Joseph Scafidi, Susanna Scafidi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ASN neuro, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Javier Allende LabastidaDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Regina F FernandezThe Michael V. Johnston Center for Developmental Neuroscience, Kennedy Krieger Institute, Baltimore, MD, USA.
Tiffany ChuDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Noelle PuleoThe Michael V. Johnston Center for Developmental Neuroscience, Kennedy Krieger Institute, Baltimore, MD, USA.
Maria ShishikuraDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael J WolfgangDepartment of Physiology, Pharmacology & Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Joseph ScafidiThe Michael V. Johnston Center for Developmental Neuroscience, Kennedy Krieger Institute, Baltimore, MD, USA.
Susanna ScafidiDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

Coordination of hepatic fatty acid metabolismR01DK120530 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WOLFGANG, MICHAEL J. · 2020 to 2024
$2.0M
Coordination of fatty acid metabolism following neonatal brain injury from preterm birthR01NS125653 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Joseph Scafidi, Susanna Scafidi · 2022 to 2026
$1.9M
Role of fatty acid oxidation after pediatric head injuryR01NS110808 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SCAFIDI, SUSANNA · 2019 to 2023
$1.8M
Mechanisms of metabolic adaptation after traumatic brain injuryR01NS111230 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SCAFIDI, SUSANNA · 2019 to 2023
$1.8M
Novel roles of hepatic fatty acid oxidationR56DK138507 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WOLFGANG, MICHAEL J. · 2024 to 2024
$409k
NIDDK NIH HHS R01 DK120530NIDDK NIH HHS R56 DK138507NINDS NIH HHS R01 NS110808NINDS NIH HHS R01 NS111230NINDS NIH HHS R01 NS125653
6 · The paper itself

Abstract

Neurogenesis in the dentate gyrus of the hippocampus is a conserved and highly regulated process throughout the lifespan. Hippocampal neural stem and progenitor cells (NSPCs) can either transition into an activated proliferative state or remain quiescent. Accumulating data suggests that mitochondrial fatty acid β-oxidation is important in maintaining NSPCs quiescence under normal physiological conditions; however, the contribution of this pathway in NSPCs following brain injury remains unknown. While severe traumatic brain injury (TBI) is characterized by increased NSPCs proliferation in the hippocampus, the extent of this proliferative response after mild TBI, the most prevalent form of TBI, has not been fully delineated. Using closed head injury as a model of mild TBI and a brain-specific knockout mouse of carnitine palmitoyltransferase 2 (CPT2; an obligate gene in mitochondrial fatty acid β-oxidation), we investigated the role of fatty acid oxidation in hippocampal NSPCs proliferation in naïve and injured male and female mice. Our results show that loss of CPT2 in the brain does not affect hippocampal proliferation in naïve mice. Furthermore, mild TBI upregulates proliferation at day 3 post-injury, and is further increased only in male CPT2-deficient mice. Despite the post-injury increase in hippocampal NSPCs proliferation in CPT2

Indexed as

Brain Injuries, TraumaticCell ProliferationFatty AcidsNeural Stem CellsNeurogenesisAnimalsCarnitine O-PalmitoyltransferaseDisease Models, AnimalFemaleHippocampusMaleMiceMice, Inbred C57BLMice, KnockoutOxidation-ReductionCarnitine O-PalmitoyltransferaseCPT1B protein, mouseFatty AcidsFatty acid oxidationhippocampusmild traumatic brain injuryneural stem and progenitor cellsproliferation

Identifiers

PMID41553195
PMCPMC12818800

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.