Evidence map›Paper›PMID 41554331›Full record

ArticleContemporary clinical trials2026

Rationale and design of a three-arm randomized clinical trial to improve drug use and retention in care of people with opioid use disorder on buprenorphine: OVERCOME II study.

Irene Pericot-Valverde, Moonseong Heo, Kaileigh A Byrne, Alison Karasz, Angelica Perez, Snehal Lopes, Megan Groome, Sarah Voss, Ashley King, Katy Barnick and 1 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06102200 (Prisma Health Clemson University), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06102200 nacompletednot on this map

Prisma Health Clemson University

TypeinterventionalSponsorPrisma Health-UpstateRan2023 to 2025Enrolled92ConditionsStandard of Care, Standard of Care + CBT4CBT, Standard of Care + CBT4CBT + RCArmsCBT4CBT, RC, Sandard of care
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Irene Pericot-ValverdeDepartment of Psychology, College of Behavioral, Social, and Health Sciences, Clemson University, Clemson, SC 29634, USA.
Moonseong HeoDepartment of Public Health, College of Behavioral, Social, and Health Sciences, Clemson University, Clemson, SC 29634, USA. Electronic address: mheo@clemson.edu.
Kaileigh A ByrneDepartment of Psychology, College of Behavioral, Social, and Health Sciences, Clemson University, Clemson, SC 29634, USA.
Alison KaraszDepartment of Family Medicine and Community Health, UMass Chan Medical School, Worcester, MA 01655, USA.
Angelica PerezAddiction Medicine Center, Department of Medicine Prisma Health-Upstate, Greenville, SC 29605, USA.
Snehal LopesDepartment of Public Health, College of Behavioral, Social, and Health Sciences, Clemson University, Clemson, SC 29634, USA.
Megan GroomeAddiction Medicine Center, Department of Medicine Prisma Health-Upstate, Greenville, SC 29605, USA.
Sarah VossDepartment of Psychology, College of Behavioral, Social, and Health Sciences, Clemson University, Clemson, SC 29634, USA.
Ashley KingAddiction Medicine Center, Department of Medicine Prisma Health-Upstate, Greenville, SC 29605, USA.
Katy BarnickAddiction Medicine Center, Department of Medicine Prisma Health-Upstate, Greenville, SC 29605, USA.
Alain H LitwinDepartment of Psychology, College of Behavioral, Social, and Health Sciences, Clemson University, Clemson, SC 29634, USA; Addiction Medicine Center, Department of Medicine Prisma Health-Upstate, Greenville, SC 29605, USA; Department of Medicine, University of South Carolina School of Medicine, Greenville, SC 29605, USA.

Funding

Development of an integrated intervention involving recovery coaching and cognitive behavioral therapy for opioid use disorderR34DA057662 · NIDA · CLEMSON UNIVERSITY · PI HEO, MOONSEONG, LITWIN, ALAIN HARRIS · 2022 to 2022
$897k
NIDA NIH HHS R34 DA057662
6 · The paper itself

Abstract

Medications for opioid use disorder (MOUD) are effective in reducing opioid use, but retention to buprenorphine remains suboptimal among OUD patients. Integration of computer-based cognitive behavioral therapy (CBT4CBT) and utilization of recovery coaches (RCs), called RC + CBT4CBT-Buprenorphine, into OUD care could improve drug use and retention in care among patients taking buprenorphine. The OVERCOME II (OUD Intervention Recovery Coach CBT and OUD Medications II) study is a three-arm 1:1:1 randomized clinical trial designed to test the remotely delivered RC + CBT4CBT-Buprenorphineintervention as an adjunct to buprenorphine treatment for patients with OUD, and to compare it with both CBT4CBT-Buprenorphine alone and the treatment as usual (TAU). Patients (n = 90) who have newly initiated buprenorphine in the past 90 days are planned to be recruited. Comprehensive measures on demographics, various conditions/constructs, and outcomes will be collected from medical charts and survey instruments. Additionally, neurophysiological outcomes and neurocognitive inhibitory controls will be measured using the NEXUS-10-MKII physiological system with BioTrace+ software and computerized Drug Go/NoGo Task, respectively. Qualitative analysis of interviews with N = 2 RCs and N = 15 participants will also be conducted. The study will be the first to examine the effectiveness of the remotely delivered RC + CBT4CBT-Buprenorphine intervention on drug use (during the first 8 weeks and follow-up) and retention in care, as well as on various neurophysiological and cognitive performances in comparison to CBT4CBT-Buprenorphine alone and TAU. Clinical Trial Registration: This study was registered at ClinicalTrials.gov (NCT06102200, www.clinicaltrials.gov/) on August 31, 2023, with a title, An Integrated Intervention Involving Recovery Coaching and Cognitive Behavioral Therapy for Opioid Use Disorder (OVERCOME 2).

Indexed as

BuprenorphineCognitive Behavioral TherapyOpiate Substitution TreatmentOpioid-Related DisordersRetention in CareAdultCombined Modality TherapyFemaleHumansMaleRandomized Controlled Trials as TopicBuprenorphineBuprenorphineCB4CBTNeurophysiologyOpioid use disorderRecovery coachTAU

Identifiers

PMID41554331
PMCPMC13335582

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.