Evidence map›Paper›PMID 41554808›Full record

ArticleScientific reports2026

Association of low progesterone levels and periodontal disease with threatened preterm labor.

Nodoka Sugiyama, Satsuki Kato, Shintaro Shimizu, Osamu Uehara, Kozue Hasegawa-Nakamura, Yoshinori Shirakata, Kazuyuki Noguchi, Masayuki Hatae, Hiroshige Kakinoki, Masato Kamitomo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Periodontal health and disease.Scientific reports · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nodoka Sugiyama *Division of Periodontology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan.
Satsuki Kato *Division of Periodontology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan.
Shintaro ShimizuDivision of Periodontology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan.
Osamu UeharaDivision of Disease Control and Molecular Epidemiology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan.
Kozue Hasegawa-NakamuraDepartment of Periodontology, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutic Course, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Yoshinori ShirakataDepartment of Periodontology, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutic Course, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Kazuyuki NoguchiDepartment of Periodontology, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutic Course, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Masayuki HataeKaneko Clinic, Kagoshima, Japan.
Hiroshige KakinokiKakinoki Hospital, Kagoshima, Japan.
Masato KamitomoDepartment of Obstetrics and Gynecology, Kagoshima City Hospital, Kagoshima, Japan.
Yasushi FuruichiDental Education Development, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan.
Toshiyuki NagasawaDivision of Periodontology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan. nagasawa@hoku-iryo-u.ac.jp.

Funding

Grants-in-Aid for Scientific Research (C) #22K10004
6 · The paper itself

Abstract

Periodontal disease has been reported to increase the risk of threatened preterm labor (TPL). However, studies analyzing the oral, vaginal, and rectal lumen commensal flora in women with TPL are limited. In this study, a total of 60 women were enrolled, including 30 with TPL and 30 without TPL. We assessed periodontal clinical parameters, salivary hormone levels, and the microbiome using next-generation sequencing. Probing pocket depth (PPD) and bleeding on probing were greater in the TPL than in the non-TPL group. The TPL group was associated with lower progesterone levels and an increase in PPD ≥ 4 mm. Significant differences in alpha diversity in only vaginal Faith's phylogenetic diversity, and significant differences in beta diversity at all sites were observed. ANCOM showed decreased Lactobacillales in the saliva and Bifidobacterium in the rectal lumen, and increased Staphylococcus in the oral cavity and vagina in the TPL group. The peptidoglycan synthesis pathway was significantly upregulated in the oral and vaginal tissues in the TPL group. Overall, the TPL group had lower progesterone levels and more severe periodontal disease; furthermore, the low progesterone levels in the TPL group were associated with oral and vaginal dysbiosis of the microbiota.

Indexed as

Obstetric Labor, PrematurePeriodontal DiseasesProgesteroneAdultFemaleHumansMicrobiotaMouthPregnancySalivaVaginaProgesteroneOral microbiomePeriodontal diseaseProgesteroneRectal lumen microbiomeThreatened premature laborVaginal microbiome

Identifiers

PMID41554808
PMCPMC12891729

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.