ArticleBMC genomics2026
Elevation-associated shifts in plasma metabolite abundance and lung gene expression in the Xizang plateau frog, Nanorana parkeri.
Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundCompared to other amphibians, the Xizang plateau frog, Nanorana parkeri, is the highest elevation-dwelling amphibian species known to date (up to 5,100 m), offering a valuable model for understanding ectotherm adaptation to extreme environments. Here, we compared plasma metabolomes and lung transcriptomes of frogs between higher (4,600 m) and lower (3,400 m) elevations. We also assayed key metabolites (glucose, lactate, NADH, β-hydroxybutyrate) in the plasma and inferred the metabolic flux of central metabolic pathways.
resultsPlasma metabolomics revealed significant elevation-related differences, identifying 222 differential metabolites. High-elevation frogs exhibited 37% higher glucose but 32% and 33% lower lactate and β-hydroxybutyrate, respectively, alongside reduced glycolytic and fatty acid metabolism fluxes. Lung transcriptomic analysis identified 1,618 differentially expressed genes, with broad down-regulation of glycolysis, TCA cycle, oxidative phosphorylation, fatty acid oxidation, and PPAR signaling in high-elevation frogs, indicating metabolic rate depression. Canonical hypoxia sensors (HIF1A, EGLN1-3) showed no differential expression, but transcription factors (ATF3, JUN, ARNT2) and stress-response pathways (Wnt, MAPK, and G protein-coupled receptor signaling) were up-regulated in high-elevation frogs. Increased expression of fibroblast growth factors and IGFBP2 in high-elevation individuals may indicate vascular remodeling. At higher elevation, the up-regulation of potassium/calcium channels, TRP channels, and aquaporins (AQP1, AQP4) may be linked to ion and water homeostasis. Moreover, higher expression of DNA repair-related genes (RAD18, RAD51), heat shock proteins (HSPB6, HSP40), and adhesion molecules (ADAM22, cadherins) was consistent with enhanced cellular stress tolerance under high-elevation conditions.
conclusionsThese results reveal that N. parkeri shows coordinated shifts in metabolite abundance and gene expression associated with higher elevation, providing new insights into molecular mechanisms of ectotherm adaptation to extreme environments.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.