ArticleBMC microbiology2026
Subglottic microbiota in periodontitis patients undergoing short-term endotracheal intubation: a pilot study.
Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectivesIt remains uncertain whether oral bacteria, especially in periodontitis, enter the lower respiratory tract via tracheal intubation during anesthesia. This pilot study aimed to characterize subglottic microbiota profiles in patients with or without periodontitis before and after 1-hour endotracheal intubation.
methodsFemale patients undergoing gynecological surgery with endotracheal intubation were divided into periodontitis (n = 24) and periodontally healthy control (n = 17) groups. Unstimulated saliva was collected pre-anesthesia. Subglottic lavage samples were obtained immediately after anesthesia induction (pre-intubation) and 1-hour post-intubation. Microbial composition was analyzed via 16S rRNA sequencing.
resultsStatistically significant differences were observed primarily in salivary microbiota: compared to the control group, the periodontitis group had significantly higher abundances of periodontopathogens in saliva, including Porphyromonas gingivalis, Treponema denticola, and Prevotella intermedia (all P < 0.05). Additionally, the relative abundance of the phylum Spirochaetota was five-fold higher in the saliva of periodontitis patients (0.73%) than in controls (0.14%, P < 0.05). In contrast, subglottic microbiota showed distinct compositional patterns from saliva across all groups, with Proteobacteria being the dominant phylum (65.44%–78.58% of total taxa). Post-intubation, the periodontitis group exhibited a non-significant upward trend in subglottic levels of periodontopathogens (e.g., P. gingivalis, T. denticola), whereas the control group showed a non-significant downward trend in these taxa(P > 0.05). Conclusion: This pilot study demonstrates that subglottic microbial communities differ from salivary microbiota and identifies an exploratory, non-significant trend suggestive of a potential association between periodontitis and altered subglottic periodontopathogen levels following short-duration intubation. These findings suggest a potential value in pre-anesthetic oral health assessment, though further studies with larger cohorts and clinical outcome data are required to confirm clinical relevance.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.