SynthesisBMC pediatrics2026
Effect of exercise interventions on physical function, cardiorespiratory fitness, and health-related quality of life in patients with juvenile idiopathic arthritis: a meta-analysis of randomized controlled trials.
Synthesis in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundJuvenile idiopathic arthritis (JIA) frequently leads to reduced physical ability, diminished aerobic capacity, and impaired quality of life in children. Exercise has emerged as a promising adjunctive therapy; however its overall efficacy remains uncertain.
objectiveTo assess the effects of exercise interventions on physical function, cardiorespiratory fitness, and health-related quality of life (HRQoL) in patients with JIA.
methodsA systematic search of MEDLINE, Embase, and the Cochrane Library was conducted through 1, October 2025 to identify randomized controlled trials (RCTs) evaluating exercise in JIA. Eligible studies reported outcomes for at least one of the target domains. Meta-analyses were performed using fixed- or random-effects models, and risk of bias was assessed with the Cochrane risk of bias tool RoB2.
resultsEight RCTs involving 405 participants met the inclusion criteria. Exercise interventions significantly improved functional measures, including child health assessment questionnaire (CHAQ) score (WMD = − 0.41; 95% CI: − 0.80 to − 0.03; p = 0.03) and 6-minute walk test (6MWT) distance (WMD = 26.70; 95% CI: 1.70 to 51.71; p = 0.04). Maximum heart rate (HRmax) also increased significantly (WMD = 7.27; 95% CI: 3.69 to 10.84; p < 0.01), while changes in peak oxygen consumption (VO₂peak) and health-related quality of life (HRQoL) scores were not statistically significant.
conclusionExercise interventions improve both subjective and objective measures of physical function in patients with JIA. Given the inconsistent effects on cardiorespiratory fitness and HRQoL, further high-quality RCTs are warranted to clarify long-term benefits and determine optimal implementation.
trial registrationPROSPERO registration number: CRD420251048687
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.