Evidence map›Paper›PMID 41555413›Full record

ArticleJournal of nanobiotechnology2026

Cerium-doped prussian blue nanozymes for bone regeneration and osteoprotection by Lhx2 in sutural distraction osteogenesis through multi-omics analysis.

Hanjiang Zhao, Zhiyuan Pan, Xiangyu Wang, Dan Lin, Anting Jin, Juan Mou, Jiewen Dai, Steve Gf Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hanjiang Zhao *Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China.
Zhiyuan Pan *Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China.
Xiangyu WangDepartment of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China.
Dan LinShanghai University of Medicine and Health Sciences, Shanghai, 201318, China.
Anting JinDepartment of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China. Katerinajin@foxmail.com.
Juan MouCollege of Chemistry and Materials Science, Shanghai Normal University, Shanghai, 200234, China. moujuan@shnu.edu.cn.
Jiewen DaiDepartment of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China. daijiewen@163.com.
Steve Gf ShenDepartment of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China. shengf1428@sjtu.edu.cn.

Funding

Fundamental Research Funds for the Central Universities YG2024QNA27Fund of Department of Oral and Maxillofacial Surgery 2023-02Key Laboratory of Oral Biomedical Research of Zhejiang Province Foundation 2021M007National Key R&D Program of China 2017YFB1104100National Natural Science Foundation of China 32201104National Natural Science Foundation of China 82071097Research-oriented Physicians Participating in the "Double Hundred Peoeple's Plan" at Shanghai Jiao Tong University School of Medicine 20240810Research Project of Shanghai Municipal Health Commission 20234Z0006Science and Technology Commission of Shanghai Municipality 22010502600Science and Technology Commission of Shanghai Municipality 24QA2708100Shanghai Sailing Program 24YF2737300
6 · The paper itself

Abstract

Sutural distraction osteogenesis (SDO) involves the induction of new bone formation in the suture region through external distraction, widely employed for treating craniomaxillofacial deformities such as craniosynostosis and maxillary transverse hypoplasia. Nonetheless, there remains a deficiency in effective and minimally invasive therapeutic approaches to shorten the treatment duration and minimize the risk of relapse. Prussian blue (PB) nanozymes exhibit extensive biological applications due to their superior biocompatibility and enzyme-like activity. Incorporating cerium (Ce), which possesses REDOX and osteopromoting properties, into Prussian blue nanozymes not only preserves its excellent biosafety but also enhances stem cell recruitment and bidirectional regulation of osteogenesis promotion and osteoclast inhibition. Moreover, the bidirectional regulatory effects of cerium-doped prussian blue (CePB) nanozymes are significantly amplified under mechanical tension conditions. ANANSE (Analysis Algorithm for Networks Specified by Enhancers) analysis integrating RNA-seq, ATAC-seq, and CUT&Tag data identified Lhx2 as a critical transcription factor involved in regulating osteogenic differentiation of suture‑derived stem cells (SuSCs) mediated by CePB nanozymes, which was further validated in vitro. In summary, CePB nanozymes offer a novel adjuvant therapy for craniomaxillofacial suture distraction osteogenesis. This study provides the first in-depth, comprehensive, and reliable investigation into how nanozymes regulate stem cell fate through the integration of transcriptome analysis and epigenetic sequencing.

Indexed as

Bone RegenerationCeriumFerrocyanidesLIM-Homeodomain ProteinsOsteogenesis, DistractionTranscription FactorsAnimalsCell DifferentiationMiceOsteogenesisCeriumferric ferrocyanideFerrocyanidesLIM-Homeodomain ProteinsTranscription FactorsBone regenerationBone remodelingCerium-doped prussian blue nanozymeMulti-omics analysisSutural distraction osteogenesis

Identifiers

PMID41555413
PMCPMC12853962

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.