ArticleGenome biology2026
CLAMP: predicting specific protein-mediated chromatin loops in diverse species with a chromatin accessibility language model.
Article in Genome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- CLAMP: predicting specific protein-mediated chromatin loops in diverse species with a chromatin accessibility language model.Genome biology · 2026Article
- Immune signaling as a determinant of cellular identity and tissue function.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Emerging DNA language models provide powerful tools to address the challenge of accurately predicting chromatin loops, fundamental structures governing 3D genome organization and gene regulation. Here we present CLAMP, which utilizes a deep language model pre-trained on broad cross-species chromatin accessibility data. CLAMP achieves superior performance compared to existing methods in predicting specific protein-mediated loops across 10 species, 18 proteins, and 24 cell types. CLAMP incorporates a novel CoVE explainer that reveals context-dependent genomic feature contributions, providing insights into the features driving predictions. CLAMP predictions effectively identify functionally significant chromatin loops and associated biological pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.