Evidence map›Paper›PMID 41555438›Full record

ReviewJournal of translational medicine2026

Apoptotic vesicles: from biological characteristics to clinical translational prospects.

Long-Bin Huang, Chen Kong, Mei-Feng Yang, Shuang Zhang, Ning-Ning Yue, Yuan Zhang, Cheng-Mei Tian, Dao-Ru Wei, Rui-Yue Shi, Ding-Guo Zhang and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Long-Bin Huang *Department of Gastroenterology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, 518020, China.
Chen Kong *Department of Gastroenterology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, 518020, China.
Mei-Feng Yang *Department of General Medicine, Yantian District People's Hospital, Shenzhen, Guangdong, 518020, China.
Shuang Zhang *Department of Gastroenterology, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University), Shenzhen, 518020, China.
Ning-Ning Yue *Department of Gastroenterology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, 518020, China.
Yuan ZhangDepartment of Medical Administration, Huizhou Institute of Occupational Diseases Control and Prevention, Huizhou, Guangdong, 516000, China.
Cheng-Mei TianDepartment of Emergency, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University), Shenzhen, 518020, China.
Dao-Ru WeiDepartment of Rehabilitation, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University), Shenzhen, 518020, China. weidr@126.com.
Rui-Yue ShiDepartment of Gastroenterology, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University), Shenzhen, 518020, China. ruiyueshi@126.com.
Ding-Guo ZhangDepartment of Surgical Endoscopy Center, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University), Shenzhen, 518020, China. zdg8012@sina.com.
Yu-Jie LiangDepartment of Gastroenterology, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University), Shenzhen, 518020, China. liangyjie@126.com.
Jun YaoDepartment of Gastroenterology, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University), Shenzhen, 518020, China. yj_1108@126.com.
Li-Sheng WangDepartment of Gastroenterology, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University), Shenzhen, 518020, China. wanglsszrmyy@163.com.
De-Feng LiDepartment of Gastroenterology, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University), Shenzhen, 518020, China. ldf830712@163.com.ORCID 0000-0003-3118-6840

Funding

Basic and Applied Basic Research Foundation of Guangdong Province Grant 2024A1515011554Science and Technology Innovation Committee of Shenzhen JCYJ20210324113803011Science and Technology Innovation Committee of Shenzhen JCYJ20220530151810024Science and Technology Innovation Committee of Shenzhen JCYJ20240813175903005Science and Technology Innovation Committee of Shenzhen JCYJ20250604191309013
6 · The paper itself

Abstract

backgroundApoptotic vesicles (apoVs), a specialized subtype of extracellular vesicles released during cellular apoptosis, play crucial roles in intercellular communication and immune regulation. In recent years, their functions in various physiological and pathological processes have garnered increasing attention. MAIN BODY: This review provides a comprehensive overview of the biological characteristics, formation mechanisms, and functional implications of apoVs in various diseases. It particularly emphasizes the potential clinical applications of apoVs in diagnostics and therapeutics. By integrating the latest research advancements, the review analyzes the molecular cargo packaging mechanisms of apoVs and their impact on functionality, assessing their prospects as drug carriers and immune modulators.

conclusionsBy synthesizing existing research findings, this review aims to provide a systematic theoretical foundation and practical strategies for both fundamental research and clinical translation of apoptotic vesicles. Further investigation into apoptotic vesicles is expected to offer novel insights and approaches for the diagnosis and treatment of various diseases.

Indexed as

ApoptosisExtracellular VesiclesTranslational Research, BiomedicalAnimalsHumansApoptotic vesiclesBiological characteristicsClinical translationImmune modulation

Identifiers

PMID41555438
PMCPMC12903660

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.