ArticleEuropean journal of medical research2026
Diagnostic accuracy of serum miR-23a-3p, miR-150, and miR-150-5p for diabetic osteoporosis in adults with type 2 diabetes: a retrospective single-center cohort study.
Article in European journal of medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetic osteoporosis (DOP) is a frequently under-recognized complication of type 2 diabetes (T2D). This study evaluated the association and diagnostic performance of serum miR-23a-3p, miR-150, and miR-150-5p for identifying DOP in adults with T2D.
methodsA single-center retrospective cohort included 225 adults with T2D (DOP, n = 57; non-DOP, n = 168). Serum microRNAs were quantified by qRT-PCR. Independent associations with DOP were assessed using multivariable logistic regression. Discrimination was evaluated by ROC analysis for each miRNA and a combined model, and calibration was examined.
resultsCompared with the non-DOP group, the DOP group was older, had a longer diabetes duration, and had higher fasting plasma glucose and HbA1c (all P < 0.05). Serum miR-23a-3p, miR-150, and miR-150-5p levels were higher in DOP (all P < 0.001) and remained independently associated with DOP (miR-23a-3p: OR 3.71; miR-150: OR 5.32; miR-150-5p: OR 9.57). The AUCs were 0.77 (miR-23a-3p), 0.88 (miR-150), and 0.80 (miR-150-5p). The combined model achieved an AUC of 0.95 with 0.95 sensitivity and 0.82 specificity, with good calibration.
conclusionsSerum miR-23a-3p, miR-150, and miR-150-5p were independently associated with DOP, and their combined assessment showed excellent diagnostic discrimination. External validation and analytical standardization are required before this panel can be considered for clinical application.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.