Evidence map›Paper›PMID 41555457›Full record

ArticleAlzheimer's research & therapy2026

Circulating inflammatory proteins predict dementia risk, and are linked to structural brain changes and modifiable risk factors.

Dorsa Abdolkarimi, Yue Liu, Lachlan Gilchrist, Sara Calhas, Sheena Waters, Charles R Marshall, Petroula Proitsi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dorsa AbdolkarimiCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Yue LiuCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Lachlan GilchristCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Sara CalhasCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Sheena WatersCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Charles R Marshall *Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK. Charles.marshall@qmul.ac.uk.
Petroula Proitsi *Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK. p.proitsi@qmul.ac.uk.

Funding

MRC Doctoral Training Partnership MR/W007045/1
6 · The paper itself

Abstract

introductionSystemic inflammation has been identified as a key factor in neurodegeneration but the value of circulating inflammatory proteins in dementia risk prediction and their causal role has not been elucidated.

methodsWe leveraged proteomic data from 43,685 UK Biobank participants to investigate associations between 728 Olink inflammatory proteins and incident dementia using Cox proportional-hazards (Cox-PH) models. We used Cox-PH with LASSO regularisation to calculate a sparse signature of inflammatory proteins (ProSig) predicting incident dementia. Linear regressions assessed the association between ProSig and individual proteins with brain image-derived phenotypes and Brain Age in participants with available neuroimaging data (n = 4,106). Formal mediation analyses investigated whether inflammatory proteins mediated associations between genetic and modifiable risk factors and dementia outcomes. Mendelian randomisation (MR) tested the causal relationship between inflammatory proteins and dementia outcomes.

results218 inflammatory proteins were individually associated with incident dementia in Cox-PH models (p

conclusionsBy triangulating evidence, this study shows that inflammatory proteins improve dementia risk prediction and play heterogeneous roles in dementia pathophysiology.

Indexed as

BrainDementiaInflammationAgedBiomarkersFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProteomicsRisk FactorsUK BiobankBiomarkersEarly detectionImagingIncident dementiaInflammationMachine learningProteomics

Identifiers

PMID41555457
PMCPMC12879394

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.