Evidence map›Paper›PMID 41555511›Full record

ArticleJournal of microbiology and biotechnology2026

Upcycling Fermented Adlay Bran Ethanol Extract Residues Promotes Human Dermal Fibroblast Proliferation and Wound Healing.

Ji Yun Van, Kyoung Mi Moon, Yerin Seong, Seungjin Jeong, Suhyeon Baek, Minsup Lee, Sang Gil Lee, Chun Whan Choi, Bonggi Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ji Yun VanDepartment of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Kyoung Mi MoonDepartment of Food and Nutrition, Pukyong National University, Busan 48513, Republic of Korea.
Yerin SeongDepartment of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Seungjin JeongDepartment of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Suhyeon BaekDepartment of Food and Nutrition, Pukyong National University, Busan 48513, Republic of Korea.
Minsup LeeDepartment of Molecular & Cellular Physiology, Louisiana State University Health Shreveport, Shreveport, Louisiana, USA.
Sang Gil LeeDepartment of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Chun Whan ChoiNatural Product Research Team, Biocenter, Gyeonggido Business and Science Accelerator, Gyeonggi-Do, Republic of Korea.
Bonggi LeeDepartment of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing, critical for skin recovery after surgery, trauma, and chronic damage, proceeds through inflammation, proliferation, and remodeling phases. In this study, we focused on the proliferative phase using fermentation extracts from the residuals of Adlay bran ethanol extraction and their solvent fractions. Among them, the butanol fraction exhibited the strongest antioxidant activity and significantly enhanced the proliferation of human dermal fibroblasts, as confirmed by a real-time wound closure assay. Cell cycle analysis revealed an increased proportion of cells in the S-phase and upregulation of Cyclin A1 and Cyclin B2 mRNA, indicating accelerated progression toward the G2/M phase. We then purified the butanol fraction using C18 MPLC and HPLC and identified uridine and deoxythymidine as the main components by LC-MS/MS and NMR analysis. These nucleosides derived from fermented adlay bran residues directly promote fibroblast proliferation, highlighting their potential as sustainable bioactive compounds for skin regeneration and functional ingredient development.

Indexed as

Cell ProliferationFibroblastsPlant ExtractsWound HealingAntioxidantsCell CycleCells, CulturedEthanolFermentationHumansSkinTandem Mass SpectrometryUridineAntioxidantsEthanolPlant ExtractsUridineAdlay branDeoxythymidineFibroblast proliferationSkin regenerationUridineWound healing

Identifiers

PMID41555511
PMCPMC12828326

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.