Evidence map›Paper›PMID 41555550›Full record

ReviewChannels (Austin, Tex.)2026

An update on regulation of the polymodal TRPV4 channel by protein phosphorylation.

Aravind Parthasarathy, David X Zhang

Abstract readReview
In one paragraph

Review in Channels (Austin, Tex.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Aravind ParthasarathyDepartment of Medicine, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI, USA.
David X ZhangDepartment of Medicine, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI, USA.

Funding

TRP Channels In The Regulation of Vascular ToneR01HL096647 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI ZHANG, DAVID X. · 2011 to 2024
$5.5M
Molecular mechanisms of polymodal TRP channels in regulation of microvascular endothelial functionR01HL181985 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI David X. Zhang · 2025 to 2026
$1.4M
NHLBI NIH HHS R01 HL096647NHLBI NIH HHS R01 HL181985
6 · The paper itself

Abstract

TRPV4 is a polymodal Ca

Indexed as

TRPV Cation ChannelsAnimalsHumansPhosphorylationTRPV4 protein, humanTRPV Cation Channelsarachidonic acid (AA)hypotonic cell swellingPKAPKCprotein kinasesTransient receptor potential vanilloid 4 receptors (TRPV4)

Identifiers

PMID41555550
PMCPMC12818809

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.