Evidence map›Paper›PMID 41555802›Full record

ArticleJournal of Korean medical science2026

Hand Grip Strength Predicts Cognitive Decline in Subjective Cognitive Decline: 2-Year Follow-up Results.

Eun Ye Lim, Yun Jeong Hong, Jee Hyang Jeong, Kee Hyung Park, SangYun Kim, Min Jeong Wang, YongSoo Shim, Seong Hye Choi, Dong Won Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eun Ye LimDepartment of Neurology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-4972-7070
Yun Jeong HongDepartment of Neurology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-4996-4981
Jee Hyang JeongDepartment of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-7945-6956
Kee Hyung ParkDepartment of Neurology, Gachon University Gil Hospital, Incheon, Korea.ORCID https://orcid.org/0000-0001-6847-6679
SangYun KimDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.ORCID https://orcid.org/0000-0002-9101-5704
Min Jeong WangDepartment of Neurology, Roa Neurology Clinic, Seongnam, Korea.ORCID https://orcid.org/0000-0001-7215-4883
YongSoo ShimDepartment of Neurology, St.Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0001-5642-5401
Seong Hye ChoiDepartment of Neurology, Inha University College of Medicine, Incheon, Korea. seonghye@inha.ac.kr.ORCID https://orcid.org/0000-0002-0680-8364
Dong Won YangDepartment of Neurology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. neuroman@catholic.ac.kr.ORCID https://orcid.org/0000-0002-4733-7298

Funding

Ministry of Health and Welfare HI18C0530
6 · The paper itself

Abstract

backgroundHand grip strength (HGS) has been proposed as a potential clinical marker for cognitive decline. However, its association with domain-specific cognitive changes and underlying amyloid pathology remains unclear.

methodsThis longitudinal study included 107 older adults with subjective cognitive decline (SCD) who completed a 24-month follow-up. Participants were categorized based on the presence of HGS weakness using Asian Working Group of Sarcopenia criteria. Logistic regression analyses were performed to examine the association between baseline HGS and cognitive decline across multiple domains, adjusting for relevant covariates. Repeated measures analysis of variance evaluated longitudinal changes in neuropsychological performance.

resultsParticipants with HGS weakness had significantly higher amyloid positron emission tomography (PET) positivity (47.1% vs. 18.9%,

conclusionHGS weakness is associated with cognitive decline, particularly in visuospatial and executive domains, and may serve as an early indicator of amyloid-related neurodegeneration in older adults with SCD. HGS assessment could be a practical clinical tool for identifying individuals at risk, especially when amyloid PET is not available.

Indexed as

Cognitive DysfunctionHand StrengthAgedAged, 80 and overFemaleFollow-Up StudiesHumansLogistic ModelsLongitudinal StudiesMaleNeuropsychological TestsOdds RatioPositron-Emission TomographyAlzheimer DiseaseCognitive DeclineHand Grip StrengthSubjective Cognitive Decline

Identifiers

PMID41555802
PMCPMC12815899

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.