SynthesisDialogues in clinical neuroscience2026
Functional brain alterations in anxious depression: Insights from whole-brain fMRI and meta-analysis.
Synthesis in Dialogues in clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The effects of nicotine exposure on depression: An integrative analysis combining network toxicology, molecular docking, and Mendelian randomization.Tobacco induced diseases · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of our study was to investigate neurobiological markers and gender difference for diagnosing anxious major depressive disorder (aMDD) through a meta-analysis.
methodsWe systematically searched multiple databases for whole-brain neuroimaging studies comparing anxious major depression disorder (aMDD), pure MDD, and healthy controls, with publication dates through December 2024. We extracted brain coordinates and their corresponding peaks, for further analysis using the Seed-based d Mapping software package.
resultsA total of 11 studies were included in this study, encompassing 829 aMDD patients, 681 MDD patients, and 865 healthy controls. The meta-analysis revealed that aMDD patients exhibited increased functional alteration in the left middle temporal gyrus compared to individuals diagnosed with MDD. In the comparison between individuals with aMDD and healthy controls, the meta-analysis revealed increased functional alteration in the anterior commissure and decreased functional alteration the right middle frontal gyrus. Furthermore, the meta-regression analysis revealed heightened neural activity of the left middle cingulate gyrus and right anterior thalamic regions, as well as weakened neural activity of the left rolandic operculum in females with aMDD compared to the control group.
conclusionsWe identified specific functional alterations in brain regions that may serve as potential neurobiological markers for aMDD and associated differences.
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