Evidence map›Paper›PMID 41555861›Full record

ArticleCanadian journal of kidney health and disease2026

Randomized Controlled Trial of Intradialytic Cycling as Kidney Exercise Rehabilitation for Cardiac Stunning in Hemodialysis (TICKERS_HD): A Clinical Research Protocol.

Paul N Bennett, Jarrin D Penny, Christopher W McIntyre, Jessica Vanderlinden, Megan S Borkum, Gisell Castillo, David Collister, Bonnie Corradetti, Todd A Duhamel, Haley Farion and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of kidney health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Paul N BennettUniversity of South Australia, Adelaide, Australia.ORCID https://orcid.org/0000-0001-9174-3499
Jarrin D PennyLilibeth Caberto Kidney Clinical Research Unit, London Health Sciences Centre, Arthur Labatt Family School of Nursing, University of Western Ontario, London, Canada.
Christopher W McIntyreLilibeth Caberto Kidney Clinical Research Unit, London Health Sciences Centre, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.
Jessica VanderlindenDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.ORCID https://orcid.org/0000-0003-4167-8697
Megan S BorkumDivision of Nephrology, University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0003-0082-554X
Gisell CastilloClinical Epidemiology Program, Ottawa Hospital Research Institute, ON, Canada.ORCID https://orcid.org/0000-0002-0739-0393
David CollisterDivision of Nephrology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Bonnie CorradettiMedicine Program Improvement and Integration Network, Calgary, AB, Canada.
Todd A DuhamelFaculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, Canada.
Haley FarionDepartment of Internal Medicine, University of Manitoba, Winnipeg, Canada.ORCID https://orcid.org/0009-0002-9416-2205
Emilie FordDepartment of Internal Medicine, University of Manitoba, Winnipeg, Canada.
Eric GarciaDepartment of Internal Medicine, University of Manitoba, Winnipeg, Canada.
Ruth GetachewDepartment of Internal Medicine, University of Manitoba, Winnipeg, Canada.ORCID https://orcid.org/0009-0003-6986-1386
Shilpanjali JesudasonCentral Northern Adelaide Renal and Transplant Service, University of Adelaide, SA, Australia.
Mercedeh KiaiiDivision of Nephrology, University of British Columbia, Vancouver, Canada.
Richard Le LeuCentral Northern Adelaide Renal and Transplant Service, University of Adelaide, SA, Australia.
Justin PresseauClinical Epidemiology Program, Ottawa Hospital Research Institute, ON, Canada.
Claudio RigattoDepartment of Internal Medicine, University of Manitoba, Winnipeg, Canada.ORCID https://orcid.org/0000-0002-8306-8072
Ashley K SeitzDepartment of Internal Medicine, University of Manitoba, Winnipeg, Canada.
Mitra ShiraziDepartment of Cardiology, Royal Adelaide Hospital, SA, Australia.
Anita SoniCardiac Sciences Manitoba, University of Manitoba, Winnipeg, Canada.
Krista StewartShared Health Manitoba, Winnipeg, Canada.
Brett TarcaAlliance for Research in Exercise, Nutrition and Activity, Allied Health and Human Performance, University of South Australia, Adelaide, Australia.
Karthik TennankoreDepartment of Medicine, Dalhousie University, Halifax, NS, Canada.ORCID https://orcid.org/0000-0002-7919-6709
Nancy VerdinMedicine Program Improvement and Integration Network, Edmonton, AB, Canada.
Reid WhitlockChronic Disease Innovation Centre, Winnipeg, MB, Canada.ORCID https://orcid.org/0000-0002-7046-0358
Ken WilundSchool of Nutritional Sciences at the University of Arizona, Tucson, USA.
Stephanie ThompsonDivision of Nephrology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.ORCID https://orcid.org/0000-0003-3109-6837
Jennifer M MacRaeCumming School of Medicine and Department of Cardiac Sciences, University of Calgary, Alberta, Canada.
Clara BohmDepartment of Internal Medicine, University of Manitoba, Winnipeg, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: People with hemodialysis-dependent kidney failure experience significantly higher cardiovascular (CV) morbidity, mortality, symptom burden, and cognitive impairment compared to the general population. Hemodialysis-induced ischemia contributes to myocardial stunning, which worsens CV outcomes. Intradialytic cycling has the potential to mitigate cardiac stunning, but its effects have not been assessed in randomized controlled trials (RCTs). Methods: This multicenter RCT evaluates the impact of 12 weeks of intradialytic cycling on hemodialysis-induced myocardial stunning. The study will recruit 160 adults (80 intervention and 80 control) receiving maintenance hemodialysis at five Canadian centers and one Australian center. Outcome assessments are conducted at baseline, 12 weeks, and 16 weeks. An intervention implementation process evaluation is part of this study. Outcomes: The primary outcome is change in number of regional wall motion abnormalities (RWMAs) at peak hemodialysis stress from baseline to 12 weeks. Secondary outcomes include changes in cognitive function, hemodialysis recovery time, and symptom burden. Statistical Analysis: Change in number of RWMAs at peak hemodialysis stress from baseline to 12 weeks are compared between study groups using an independent 2-tailed Conclusion: Compared with standard care, we anticipate that intradialytic cycling will decrease myocardial stunning, resulting in improved symptom burden, and functional and cognitive status. This trial provides critical evidence regarding the benefits and feasibility of exercise during hemodialysis, potentially informing clinical practice, and guidelines for hemodialysis care.

Indexed as

cognitive impairmentdialysis-related symptomsend-stage kidney diseasehemodialysisintradialytic exercisemyocardial stunningrandomized controlled trial

Identifiers

PMID41555861
PMCPMC12812203

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.