Evidence map›Paper›PMID 41555913›Full record

ArticleMDM policy & practice

Cost-Effectiveness of Metoclopramide, Paracetamol, and Ceftriaxone for the Prevention of Infections and Fever in Elderly Patients with Acute Stroke.

Mathyn Vervaart, Jeroen C de Jonge, Philip M Bath, Hans Olav Melberg, Hendrik Reinink, Wouter M Sluis, Lisa J Woodhouse, H Bart van der Worp, Anne Hege Aamodt, PRECIOUS Investigators

Abstract read
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In one paragraph

Article in MDM policy & practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mathyn VervaartClinical Trial Unit, Oslo University Hospital, Oslo, Norway.ORCID https://orcid.org/0000-0003-2678-0132
Jeroen C de JongeDepartment of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, Netherlands.
Philip M BathStroke Trials Unit, Mental Health & Clinical Neurosciences, School of Medicine, University of Nottingham, UK.
Hans Olav MelbergDepartment of Community Medicine, The Arctic University of Norway, Tromsø, Norway.
Hendrik ReininkDepartment of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, Netherlands.
Wouter M SluisDepartment of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, Netherlands.
Lisa J WoodhouseStroke Trials Unit, Mental Health & Clinical Neurosciences, School of Medicine, University of Nottingham, UK.
H Bart van der WorpDepartment of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, Netherlands.
Anne Hege AamodtDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
PRECIOUS Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Highlights: Prophylactic combination therapy with metoclopramide, paracetamol, and ceftriaxone may be the most cost-effective strategy for preventing infections and fever in elderly patients with acute stroke.There is substantial decision uncertainty, primarily driven by uncertainty regarding the treatment effects on functional outcome (modified Rankin Scale, mRS).Value-of-information analysis indicates that the value of reducing uncertainty through a new study on acute phase mRS scores is very high.

Indexed as

cost-effectivenessdecision modelingeconomic evaluationstrokevalue of information

Identifiers

PMID41555913
PMCPMC12812187

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.