Evidence mapPaperPMID 41555955Full record

ReviewCancer innovation2026

Potential Targets and Biomarkers of Radionuclide Therapy in Breast Cancer.

Yujing Tan, Cheng Zeng, Jiani Wang, Fei Ma

Abstract readReview
In one paragraph

Review in Cancer innovation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yujing TanDepartment of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.
Cheng ZengDepartment of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.
Jiani WangDepartment of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.
Fei MaDepartment of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.ORCID https://orcid.org/0000-0001-9432-1902

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, multidisciplinary treatment strategies have profoundly improved drug responses and survival outcomes of breast cancer (BC) patients. However, there is an urgent need for novel therapies for BC patients who are heavily treated or develop resistance to conventional treatment regimens. Radionuclide therapy (RT) and targeted radionuclide therapy (TRT) have emerged as paradigm-shifting therapeutic approaches for BC, which enable functions of both imaging and localised treatment. They utilise radionuclides that can selectively bind to biomarkers overexpressing on BC cells, allowing precise delivery and localised tumour irradiation. Moreover, several types of radionuclides possess 'cross-fire' effects that result in the eradication of neighbouring tumour cells lacking the biomarker expression. In the current review, we summarise the potential biomarkers for the development of RT and TRT that can be employed in the treatment of BC, including receptor markers of ER, PR and HER2, together with other markers of Trop2, PD-1, EGFR, GRPR and PSMA.

Indexed as

breast cancerradionuclide therapytargeted radionuclide therapy

Identifiers

PMID41555955
PMCPMC12812163

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.