Evidence map›Paper›PMID 41556136›Full record

ArticleMolecular oncology2026

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan-cancer.

Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C Papadimitriou and 1 more

Abstract read
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In one paragraph

Article in Molecular oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ishita GuptaInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Yang SongInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Madeleine NdahayoInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Anirudh SaxenaInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Theresa GuoDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
Dylan Z KelleyDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
Jessica GoreInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Andrew HenniganInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Alexa AndersonInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
John C PapadimitriouDepartment of Pathology, University of Maryland School of Medicine, University of Maryland Medical Center, Baltimore, MD, USA.
Daria A GaykalovaInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-5037-0147

Funding

American Cancer Society RSG-21-020-01-MPCDivision of Cancer Prevention, National Cancer Institute 30006561Foundation for the National Institutes of Health R01DE033426
6 · The paper itself

Abstract

PIK3R1, a regulatory subunit of class IA phosphoinositide-3-kinase (PI3K), undergoes alternative splicing to generate multiple isoforms, primarily p85α and p55α. The canonical isoform p85α associates with the catalytic subunit p110α to form the active PI3K complex, which regulates key cellular functions such as growth, proliferation, survival, and metabolism. In this study, we performed a comprehensive pan-cancer analysis integrating transcriptomic, proteomic, and genomic data to investigate the expression patterns of p85α and its splicing variant, p55α, and their associations with clinical outcomes. Our findings reveal that while p85α expression is significantly reduced, p55α is elevated in tumors as compared to normal samples. These alterations are linked to poor prognosis across multiple cancer types. Notably, we observed racial disparities in expression patterns, with African American patients exhibiting more pronounced downregulation of p85α and upregulation of p55α than European Americans, potentially contributing to differential clinical outcomes. This is the first study to systematically evaluate p85α and p55α expression across diverse cancers and populations, highlighting the role of alternative splicing in PI3K pathway dysregulation and its relevance to cancer progression and health disparities.

Indexed as

Alternative SplicingClass Ia Phosphatidylinositol 3-KinaseGene Expression Regulation, NeoplasticNeoplasmsPhosphatidylinositol 3-KinasesHumansProtein IsoformsClass Ia Phosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesPIK3R1 protein, humanProtein Isoformscancerp55αp85αPIK3R1racesplicing variant

Identifiers

PMID41556136
PMCPMC13155144

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.